Tuesday, October 3, 2023

A drug to treat erectile dysfunction improves sugar levels in type 2 diabetes

A group of patients with type 2 diabetes “significantly improved” their blood sugar levels when treated with high doses of tadalafil, according to the results of a pilot study conducted by researchers at the Swedish University of Gothenburg. Which he released today.

Tadalafil is one of the active pharmaceutical ingredients known as “PDE5 (phosphodiesterase type 5) inhibitors”, a group that also includes the drug “Viagra”, used to treat impotence or erectile dysfunction (ED). Is. , he specified while sharing. The results of the study, conducted in collaboration with Sahlgrenska University Hospital, published in the journal eClinicalmedicine.

The dpa agency reported that the study had 18 participants: 12 men and 6 postmenopausal women, and was “randomised, double-blind and placebo-controlled”.

They detailed that participants were first assigned by random selection to receive either a high daily dose (20 mg) of the active substance tadalafil or a placebo for six weeks.

“Self-medication with PDE5 inhibitors should never occur, because in the worst case, it can be life-threatening in combination with some other drugs. These drugs can only be bought with a prescription, And should always be prescribed by a doctor”, Per-Anders Jansson, professor at the Sahlgrenska Academy of the University of Gothenburg, began by explaining to the European portal Infosalas.

The team’s goal was to test whether tadalafil could improve patients’ insulin sensitivity.

The patients were monitored “closely” because the drug has several side effects including headache, heartburn, diarrhea, muscle and back pain, hypotension, nasal congestion, ringing in the ears and blurred vision, he explained.

It also “increases blood flow to skeletal muscle, heart and adipose tissue,” he said.

In the study they observed increased blood flow and favorable effects on the liver, where an established marker of fatty liver decreased during treatment with the drug.

Meanwhile, they maintained that tadalafil produced a “marked improvement in metabolic control” as measured by hemoglobin A1c (HbA1c) in the blood samples they took.

The investigators also observed “increased glucose uptake” with tadalafil treatment compared to placebo.

“This is a very clear long-term improvement in blood glucose levels that we could not have dreamed of after only six weeks of supplemental treatment in patients with well-controlled type 2 diabetes. What we’ve seen is consistent with what is now a fourth treatment option for type 2 diabetes,” said Jansson, who led the research.

The current primary treatment of type 2 diabetes combines lifestyle changes with the drug metformin, and other new drugs have been developed in the past 10 to 20 years as well, he points out.

In this sense, tadalafil “has potential as an adjunct to the treatments currently administered for type 2 diabetes, especially for men who suffer from erectile dysfunction,” he believed, explaining that more than 70% Men develop obesity and diabetes type 2. impotence.

Finally, the research group indicated that the results of the pilot study need to be replicated in a “larger” one in which more patients are treated for longer periods of time.

Nation World News Desk
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