Tuesday, March 28, 2023

A molecule produced during physical exercise inhibits appetite

physiological processes that are involved The interaction between exercise and appetite is still poorly understood. Now, a scientific team has identified a molecule in the blood of mice that is produced during sports practice and that Can effectively reduce food intake and obesity.Researchers from Baylor College of Medicine, Stanford School of Medicine and collaborating institutions reported the discovery of this metabolite Wednesday in the journal Nature. “It has been shown that Regular exercise helps in losing weight, controls appetite and improves metabolic profileespecially in overweight and obese people,” says study co-author Yong Xu, Baylor Professor. “If we can understand the mechanism by which exercise triggers these benefits, we will be closer.” Help many people improve their health“Stanford’s Jonathan Long explains that the team’s goal was to understand how exercise works at the molecular level so that they can capture some of its benefits; “for example, older or frail people who can’t exercise enough, may be more likely to be able to exercise.” may benefit.” a day of taking medication that can help slow osteoporosis, heart disease or other conditions.” To reach their conclusion, the scientists conducted an extensive analysis of compounds in the blood plasma of rats. An intense run on the treadmill.The most significantly induced molecule was A modified amino acid called Lac-Phe, It is synthesized from lactate (a byproduct of vigorous exercise that is responsible for muscle burning) and phenylalanine (an amino acid that is one of the building blocks of protein), a Boulder note explains. Mice with diet-induced obesity (fed a high-fat diet), a high dose of Lac-Fei reduced food intake by about 50% compared to control rats over a 12 h period, without affecting their movement or energy expenditure. When administered to rats for 10 days, Lac-Fe reduced cumulative food intake and body weight (due to loss of body fat) and Improve glucose tolerance.Researchers also recognized An enzyme called CNDP2 is involved in the production of Lac-Phi and showed that mice lacking this enzyme did not lose as much weight on an exercise regimen with the same exercise plan as a control group. The team also found strong elevations in plasma Lac-Phe levels after horse racing and physical activity in humans. Data from a human exercise group showed that Sprint exercise induced the strongest increase in plasma Lac-PheThis is followed by resistance training.” This suggests that lac-fa is an ancient and preserved system that Regulates feeding and is associated with physical activity in many animal speciesLong conclusion. The team’s next steps include finding out more about how this molecule mediates its effects in the body, including the brain: “Our goal is to learn how to modify this exercise pathway for therapeutic interventions,” Xu insists.

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