Diabetes favors soluble forms of amyloid beta, which are particularly toxic and harmful to the body. nervous tissue, This scientific finding links the disease to Alzheimer’s, according to a study involving researchers from the University of Cádiz Monica Garcia Eloza why maria vargas soriaWith Professor, Department of Physiology, UGR Juan Jose Ramos Rodriguez,
The description of the amyloid beta peptide deposition process in a combined model of Alzheimer’s and diabetes provides a new therapeutic target to work with, according to the authors.
Description of the amyloid beta peptide deposition process in a combined model of Alzheimer’s disease and diabetes offers a new therapeutic target on which to work in order to slow or stop the development of this dementia, the authors explain. It is one of the main ways to explore the future.
diabetes and dementia risk
In recent years, diabetes and prediabetes have been recognized as a risk factor for dementia, but the mechanisms mediating this association are not fully known. This work highlights one of the ways in which type 2 diabetes mellitus, or its earlier stage, prediabetes, contributes to cognitive decline and accelerate the progression of Alzheimer’s disease. This study describes a new development of amyloid beta pathology in Alzheimer’s patients who also suffer from prediabetes or type 2 diabetes.
The novelty of the obtained results is based on the detection of a distinct progression of amyloid beta pathology when only Alzheimer’s disease is encountered and a further development when this dementia is suffered simultaneously. type 2 diabetes or prediabetes.In it joint model, excess accumulation of amyloid beta peptide is seen at the vascular level, which is known as amyloid beta angiopathy. In addition, diabetes favors soluble forms of amyloid beta peptide, which are the most toxic and damaging to neuronal tissue. Modification of amyloid beta pathology leads to increased oxidative stress at the neuronal and vascular levels. All of this facilitates the breakdown of blood vessels in the brain and exacerbates the neuronal death typical of Alzheimer’s disease.
Multiphoton microscopy techniques in live animals
The research has developed in live animals thanks to a sophisticated multiphoton microscopy technique, which allows monitoring of brain pathology in the same animal and over time.
“The next question we ask ourselves is: By controlling the diabetic pathology, can we control or reduce the progression of amyloid beta pathology and its consequences?”
Juan Jose Ramos, co-author of the study
“It reduces the number of animals needed in research, certainly a big vAdvantages over more elementary techniqueswhich triples the number of animals needed to perform a similar study”, explains UGR Professor Juan José Ramos. ‘In vivo’ multiphoton microscopy is a technique within reach of some laboratories, offering data and images. that cannot be achieved with other techniques.” The next question we ask ourselves is: by controlling diabetic pathology, can we control or reduce the progression of amyloid beta pathology and its consequences ?” concluded the researcher from the University of Granada.