Thursday, February 2, 2023

A study explains what happens when you eat hypercaloric, fatty and sugary foods.

Researchers from Osaka Metropolitan University (Japan) have discovered a gene, called CREB-regulated transcription coactivator 1 (CRTC1), which is related to obesity.

According to their findings in mice published in the scientific journal FASEB JournalWhen CRTC1 is suppressed in mice, they become obese, indicating that CRTC1 functioning suppresses obesity.



However, since CRTC1 is expressed in all neurons in the brain, the specific neurons responsible for suppressing obesity and the mechanisms involved in those neurons remained unknown.

High-calorie foods (high in fat, oil and sugar) may taste good, but they often lead to overeating, which leads to obesity and serious health problems. But what triggers the brain to overeat? That’s the question these Japanese researchers asked themselves.

To elucidate the mechanism by which CRTC1 underlies obesity, a research group led by Shigenobu Matsumura of Osaka Metropolitan University’s Graduate School of Human Life and Ecology focused on neurons that express melanocortin receptor-4 (MC4R). Huh.

The researchers hypothesized that CRTC1 expression suppressed obesity in MC4R-expressing neurons because mutations in the MC4R gene are known to cause obesity.

As a result, they created a strain of mice that express CRTC1 normally, except in neurons expressing MC4R, where it is blocked, to investigate the effect that loss of CRTC1 in those neurons would have. Was on obesity and diabetes.

When fed a standard diet, mice without CRTC1 in neurons expressing MC4R showed no change in body weight compared to control mice. However, when CRTC1-deficient mice were reared on a high-fat diet, they ate more, became significantly more obese than control mice, and developed diabetes.

“This study has shown that the CRTC1 gene plays a role in the brain and is part of the mechanism that keeps us from eating high-calorie, fatty and sugary foods. We hope this will help to understand why Why do people eat more?” , commented Professor Matsumura.

Nation World News Desk
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