Wednesday, August 10, 2022

Advance knowledge of the relationship between epigenetics and key aging processes for personalized medicine

In the ‘Biological field’ section of the 62nd SEGG Congress, the symposium “Epigenetics and Aging” was held, conducted by Dr. Demaso Crespo Santiago, Professor of Cell Biology. University of Cantabria. Its content revolves around stress, aging, and epigenetics in rare forms of the disease; Methionine, …


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In the ‘Biological Sectors’ section of the 62nd Congress of SEGG, the symposium “Epigenetics and Aging” was held, which was moderated by Doctor. Damaso Crespo Santiago, Professor of Cell Biology. University of Cantabria, Its content revolves around stress, aging, and epigenetics in rare forms of the disease; Methionine, epigenetics and aging; and epigenetic changes in aging hematopoietic stem cells.

Prof. Charles Rome, Biochemist and researcher at the University of Valencia, focuses on the topic of Stress, aging and epigenetics In rare forms of the disease, as stated, “They can serve as a model for the study of many physiological and pathological processes, including aging, a very complex process with many vertices”.

In many diseases, as he explained, a regulation of oxidative stress is observed as a result of the work of mitochondria cells. This stress affects many factors such as the stability and length of telomeres, mitochondrial function, DNA damage that, if not repaired, can, in turn, lead to new oxidative stress. It can also cause cell death, which is the basis of many disease processes and is physiologically part of aging. “AndOxidative stress, along with inflammation, are the two peaks of aging“, he indicated.

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epigeneticsAs he explained, there is a part of genetics that is controlled in a particular way, it is the key to cell differentiation, showing that “genes are not everything,Epigenetics produces changes that can occur over time and for very long periods of time, but something important is that they may also be reversible., This is an important concept for precision medicine, the expert emphasized. ,This has shown that it is possible to modifyGenes attack disease for the sake of activity, to alter the life of cells, and even as something unique and unique to each individual. This is an important concept for precision medicine.“, He added.

As Prof. Rome, at another point in your speech,”Many factors of daily living can produce regulation of the epigenetic machinery and, in turn, oxidative stress and the enzymes regulating these mechanisms can be altered and lead to greater cell damage, which usually leads to age-associated diseases. gives. , metabolic regulation, diabetes, cognitive impairment, muscle loss, among others”, so”Knowledge of the progression of cell damage can help predict diseases or implement strategies that take these predictions into account.,

Diet and Epigenetic Machinery one of the speakers, researcher mariona jove font, Lleida. from University delve into “Methionine, Epigenetics and Aging”, Methionine is an essential amino acid that is included in the body through the diet and plays an important role in the formation of proteins and peptides. ,The aging process causes specific changes in methionine metabolism and epigenetics“, she claimed.

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As he noted, “The regulation of longevity is more dependent on cycle flow than on methionine levels. It is convenient to analyze all the metabolites of the methionine cycle to better understand how these processes are triggered.,

He also highlighted the importance of all those nutritional intervention ,which are able to modulate methionine levels, as they would allow the modulation of methylation processes of DNA, histones or proteins or other metabolites and affect the epigenetic imprint of cells”.

He explained that there is aDifferent regulation in both centenarian and long-lived species and this suggests changes in epigenetic processes with which the observed changes during aging may be partially understood”.

In addition, he considered it important to highlight that “Dietary interventions may modify the ‘epigenetic clock’, although they recognized the need for more studies on methionine restriction to complete the puzzle on the consequences of dietary restrictions.,

Finally, the researcher Maria Carolina Florian, Belvijs Biomedical Research Institute (IDIBEL), Dr. gave a presentation on Major epigenetic changes in aging hematopoietic stem cells, Located in the peripheral blood and bone marrow, based on how this process triggers a decline in the ability of these cells.

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