Saturday, January 28, 2023

Alpha Lipoic Acid: Fashion Medicine to “Study Better”

As one of the most powerful antioxidants, alpha-lipoic acid has many benefits for the body. It occurs naturally in the body, but we can also find it in certain foods or in supplement form. It is a peculiar fatty acid, because it is soluble in both water and fat, so it can reach all the cells of the body and protect them from oxidative stress. Due to its structure and solubility, it is able to cross the blood-brain barrier, which is why it acts as a neuroprotector and stimulates brain functionsknown as nootropic effect.

Nootropics are considered substances that contain a Positive effects on mental and cognitive abilities The long-term effects of many of them on the human body have not yet been studied, although they are used and recommended by some doctors and pharmacists.

Synapses are communication connections between neurons, and the substances that carry messages between neurons through synapses are known as neurotransmitter, Nootropics stimulate the transmission of neurotransmitters, and speeding up neurotransmitters has a direct effect on improving mood, attention, concentration, and mental abilities. Cognitive functions are also stimulated by these substances. They facilitate blood circulation in the brain and hence affect the supply of more oxygen and glucose to the neurons.

oxidative stress This occurs when free radicals become dominant in the body, causing cell damage. Specifically, the body does not have enough antioxidants to neutralize free radicals. This oxidative stress causes brain tissue deterioration, in which all aerobic cells are damaged, although the brain is more sensitive to free radicals and oxidative stress. The reason is the high metabolic activity, in which free radicals attack cells, causing damage or apoptosis (cell suicide). Alzheimer’s And this Parkinson’s There are diseases associated with the pathogenesis of aging. The biggest culprits in the development of these diseases are free radicals.

How does alpha-lipoic acid affect the brain?

Alpha-lipoic acid enhances brain function in several ways.

On the one hand, it increases the production of acetylcholine and increases the amount of glucose in brain cells, increasing mental energy, and Improving the learning process and memory.

As antioxidant, alpha-lipoic acid plays an important role in neutralizing free radicals. Free radicals cause neuronal damage, which can lead to neurodegenerative diseases. ALA not only has an antioxidant effect, but it also works by “regenerating” other antioxidants, such as vitamin C, vitamin E, glutathione, and coenzyme Q10.

Organelles called mitochondria are most important for energy production in cells. In them, the process of energy production is completed with the help of many enzymes and their co-factors. Alpha lipoic acid One of the major cofactors for cellular energy production is, So we can conclude its utmost importance. Without alpha-lipoic acid there is no energy, without energy there is no cellular life and thus disease arises.

Alzheimer’s disease is an area of ​​neurology in which scientists continue to search for a solution. According to a four-year study, alpha-lipoic acid may be the way forward. 600 mg of alpha-lipoic acid per day has been shown neuroprotective effect,

In addition, as you age, your cells tend to accumulate heavy metals, which can be released with ALA, studies show. It reduces inflammatory processes, improve cognitive functions,

Alpha-lipoic acid found in supplements is a mixture of two forms S- and R-enantiomers, The S-form has no biological effect and is formed as a by-product in the production process. The R-form is responsible for all of the mentioned effects of alpha-lipoic acid. In this way, alpha-lipoic acid is better absorbed and better utilized.

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Alpha-Lipoic Acid Side Effects

Insomnia, nausea, vomiting or diarrhea may appear as side effects, but very rarely.

ALA is often recommended to diabetics, as studies have confirmed Effects on diabetic polyneuropathy, These are patients in whom the action and neuroprotective effects of alpha-lipoic acid reduce tingling in the fingers and toes. It is also suspected that it may cause a decrease in blood sugar, so diabetics or people who have low blood sugar, It is very important that it be used under medical supervision and supervision.,

It is currently being studied extensively in other areas of medicine to assess its effectiveness, but there are great hopes that it may be used in the future to reduce body weight as well as blood cholesterol levels and other Can be done to control fat.


According to the studies published so far, ALA consumed by Orally It is possibly safe for most adults as long as it is taken for less than 4 years. It is generally well tolerated, although it can occasionally cause gastrointestinal problems or headache.

Regarding application on the skinIt is also considered safe when used for up to 12 weeks, but it has caused skin reactions in some people.

In form of interactions with other drugs, It should be noted that alcohol consumption depletes thiamine levels, which, when combined with ALA, can cause serious health problems. Therefore, if you are a regular consumer of alcohol and want to use ALA, you should also take thiamine supplements.

On the other hand, if you take medications regularly, you should consult with your doctor to assess whether there are any interactions between your daily medications and ALA. It is currently unknown what drugs it may interact with, but there is some concern when combining it with cancer, coagulation, or thyroid medication.


Although alpha-lipoic acid is produced in the body, its levels in the body decrease with age. In addition, stress, pollution and inadequate diet contribute to the build-up of free radicals and cell damage, and the brain is most vulnerable to this damage. Depression, poor mood, poor memory, and over time Alzheimer’s and Parkinson’s diseases are the results of this damage.

Alpha-lipoic acid can protect the body greatly, improve cognitive functions and slows down the processes associated with aging and loss of cellular energy.


Alpha Lipoic Acid (2019). Medline Plus.

Ahmed HH (2012). Modulatory effects of vitamin E, acetyl-L-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer’s disease in a rat model. Experimental and Toxicological Pathology, 64(6), 549-556.

Herman, R., Mungo, J., Konota, PJ, & Ziegler, D. (2010). (2014). Enantiomer-selective pharmacokinetics, oral bioavailability, and sex effects of different alpha-lipoic acid dosage forms. Clinical Pharmacology: Advances and Applications, 6, 195–204.

Salehi, B., Berke Yilmaz, Y., Antica, G., Boyungmez Toomer, T., Fawzi Mahmoodali, M., Lobine, D., Akram, M., Riaz, M., Capanoglu, E., Sharopov, F., Martins, N., Chow, WC, & Sharifi-Red, J. (2010). (2019). Insights on the use of α-lipoic acid for therapeutic purposes. Biomolecules, 9(8), 356.

Shay, KP, Morrow, RF, Smith, EJ, Smith, AR, & Hagen, TM (2009). Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochimica et Biophysica Acta, 1790(10), 1149–1160.

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