during aging, Mice, like humans, become inactive and lose muscle mass and strength.
now one Team of scientists led by Johann Auwerks at EPFL found out when As mice get older, their muscles become clogged with ceramides. Las ceramidesBest known for their use in skin care products are sphingolipids, a class of fat molecules that are not used for energy, but perform various functions in the cell.[banner-DFP_1]
researchers found that, in aging, there is a spt protein overload and others, all of which are needed to convert fatty acids and amino acids into ceramides. “Sphingolipids and ceramides are a complex but very interesting class of fats, and there is great potential to study their role in aging, as they serve many diverse functions,” A physician and lead author of the study, Dr. Pirakka-pekka says Laurila.
Next, the scientists wanted to see whether Reducing ceramide overload may prevent age-related decline in muscle function. They treated aged mice with ceramide blockers, such as myriocin and the synthetic blocker Takeda-2, and used an adeno-associated virus to specifically block ceramide synthesis in muscle. Ceramide blockers prevented muscle loss during aging, made the mice stronger, and allowed them to run longer distances while improving their coordination. ,
They examined thousands of men and women aged 70 to 80 from Helsinki
To further study this effect, the scientists measured each known gene product in muscle using a technique called RNA sequencing. “It turns out that blocking ceramide production activates muscle stem cells, causes muscles to store more protein and shifts fiber type toward fast-twitch glycolytic to produce larger, stronger muscles in aged mice.” switches.” Dr. Martin Wohlwend, lead collaborator on the study, explains. [banner-DFP_4]
Finally, scientific It remains to be seen whether reducing ceramide in muscle could also be beneficial in humans. they examined thousands Men and women aged 70-80 from Helsinki and it turns out 25% of them have a special variant of the gene that downregulates the gene products of the sphingolipid production pathways in muscle. Those who had this form of the ceramide-reducing gene were able to run longer, be stronger, and get up from a chair better, similar to mice treated with ceramide blockers. Indicate healthy aging.
“These findings are very important because they give us a strong incentive to develop inhibitors that can be tested in humans.” Dice Johann Auwerx.
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