“This effect would be related to rutin, a compound of the flavonoid group found in some plants,” says pharmaceutical chemist Maria Isabel Cardona Paredes, PhD in Pharmaceutical Sciences from the National University of Colombia (UNAL). “
The doctors, who conducted their work in collaboration with the Natural Products Technology Research Group (Techprona), explain that “the rutin contained in the extract of the Cape gooseberry calyx has many benefits for health, as well as its potential effects. Treatment of diabetes .
In investigation, it was proved that, when it is present in extracts, it behaves in a more favorable manner than when it is alone; It had increased aqueous solubility and had better stability under ambient conditions.
He adds that “this means that the extract preserves the flavonoids, which supports its inclusion in pharmaceutical preparations. In addition, it was demonstrated that the extract of Cape gooseberry calyx in a self-emulsifying system By inclusion, the concentration measurement that managed to circulate was 5.81 times higher with respect to the unprepared extract.
Something interesting about the autoemulsifiable system is that the group of compounds that make it up spontaneously form an emulsion when they come into contact with movements or fluids from the gastrointestinal system; A few drops of the oil within which, in this case, rutin is preserved, allows more of it to reach the bloodstream, thus favoring a reduction in blood sugar levels.
Another contribution of the work is that it demonstrated that the incorporation of 10% of the PDMSHEPMS copolymer into the self-emulsifying system facilitates the passage of rutin through the gastrointestinal tract, a process known as mucopenetration. Is. A copolymer is a type of polymer that is used in a wide variety of products.
“This is relevant, because on many occasions when drugs try to pass through the gastrointestinal tract, they become trapped in the mucus layer, preventing them from reaching the blood and being effective,” the researchers note.
Previous studies had already found that the Cape gooseberry calyx contained various compounds including rutin, however, this was the first time its extract was tested in a self-emulsifying system.
tested with rats
To arrive at this pharmaceutical advance, the first test carried out aimed to demonstrate whether the self-emulsifying system was capable of protecting the rutin present in the extract and encouraging it to cross the mucus lining the intestines; Stability studies and tests were done for this. in vitro With the mucus of the pig’s small intestine.
To evaluate the increase in therapeutic effect, tests were carried out on the blood of 24 laboratory rats. Eight were given orally the extract without the formula and compared to another eight who were given the autoemulsifiable system with the extract. The third group was treated with placebos. Thus, it was proved that the amount of rutin in the blood increased and remained for a long time.
“With the self-emulsifying system, we observed that rutin remained in the blood of mice for up to 72 hours, whereas with the extract it was already degraded and eliminated in only 24 hours.”
The researcher indicates that, by developing a pharmaceutical preparation, the aim is to protect the drugs and natural compounds, favoring their arrival in the bloodstream; That’s why his discovery is so important.