“We highly anticipated the problems and consequences of the ATA erection process, but were still surprised by the results of animal experiments, where the penis returned to normal erection shortly after ATA use,” he said. juetao shiis a researcher at South China University of Technology in Guangzhou and author of the study.
“The biggest advantage of ATA that we have reported is that it achieves tissue-like functions by mimicking the microstructure of natural tissues,” he said. “This design approach is not limited to biomimetic design of tunica albuginea tissues, but can be extended to many other load-bearing tissues.”
Shi said his team’s research focus has changed recently. production of biomaterials To address problems in male reproductive health, including Erectile Dysfunction, Infertility, and Peyronie’s Disease, is believed to be a connective tissue disorder that results from sexual injury. About half of men between the ages of 40 and 70 experience some form of erectile dysfunction, while about 5% suffer from Peyronie’s disease, in which scar tissue builds up in the tunica albuginea, causing pain and a number of other effects. There are
“We realized that this is an area that has received little attention, but the associated need is enormous,” Xi said.
While many previous studies have focused on repairing the urethra, Shi said less research has focused on restoring erectile function. And although doctors can treat patients with damaged tunica albuginea tissue by patches of other tissue in the body When combined with the patient’s extracellular matrix, damage occurs in these patches. Sometimes the immune system rejects them or complications arise in the donor area, and since their microstructure differs from that of the natural tunica albuginea, it is difficult for these patches to completely replace natural tissue.
To address this problem, Shi and colleagues developed an ATA based on polyvinyl alcohol, which has a crimped fiber structure similar to that of natural tissue. As a result, synthetic material is biomechanical properties Which mimics the tunica albuginea. The researchers conducted laboratory experiments to investigate the toxicity and blood compatibility of the artificial tissue, as it is designed to remain in the body for long periods of time, and determined that Should not be harmful to other tissues,
Patch made from artificial tissue restores erectile function similar to normal penile tissue
Next, they tested ATA in Bama miniature pigs with lesions in the tunica albuginea. The researchers found that patches made from the artificial tissue restored erectile function similar to normal penile tissue, suggesting that EL patch successfully replaced the function of natural tissues, The researchers analyzed the effect of the ATA patch after one month and found that the artificial tissue did not restore the microscopic structure of the surrounding natural tissue, but it developed fibrosis compared to normal tissue and a normal erection after injecting saline. Achieved it. gender.
“Results one month after the procedure show that the ATA group achieved good, although not perfect, repair results,” Shi said.
Shi noted that in penile lesions, The tunica albuginea is usually not the only tissue damaged., The surrounding nerves and the corpus cavernosum, the spongy tissue that runs along the shaft of the penis, are often damaged, making repair even more difficult.
“At this stage our work focuses on a tissue repair in the penis, and the next step will be to consider the repair of a common penile defect or the construction of an artificial penis from a holistic approach,” Shi said.
He said the researchers also plan to investigate techniques for repairing other tissues, including the heart and bladder.