The study, published in the ‘American Journal of Epidemiology’, claims that the Kovid-19 vaccination does not affect fertility.
Prospective study of couples trying to conceive found no link between Covid-19 vaccination and fertility — chances of conception by menstrual cycle — in female or male partners who received Pfizer-BioNtech, Moderna, or Johnson Received & Johnson vaccines.
Conversely, the findings indicated that COVID-19 infection in men may temporarily reduce fertility – an outcome that could be avoided through vaccination.
“Many reproductive-age individuals have cited concerns about fertility,” said study lead author Dr. Amelia Veselink, research assistant professor of epidemiology at BUSPH.
“Our study shows for the first time that COVID-19 vaccination in any partner is unrelated to fertility among couples trying to conceive through sexual intercourse. Time-to-pregnancy, regardless of vaccination status It was very similar,” she said.
Veselink and her colleagues analyzed survey data on covid-19 vaccination and infection, and fertility among female and male participants in the BUSPH-based Pregnancy Study Online (PRESTO), an ongoing NIH-funded study that looked at pregnancy. Enrolls and follows women trying to hold. Preconception up to six months after delivery.
Participants included 2,126 women in the US and Canada who provided information on sociodemographic, lifestyle, medical factors and characteristics of their partners from December 2020 to September 2021, and participants were followed in the study until November 2021.
The researchers calculated the per-monthly cycle probability of conception using the participants’ self-reported dates of previous menstruation, specific menstrual cycle length, and pregnancy status. Fertility rates in female participants who received at least one dose of the vaccine were almost the same as for female participants without vaccination.
Fertility was also similar for male partners who had received at least one dose of the COVID-19 vaccine compared to male participants who were not vaccinated. Additional analyzes that considered number of vaccine doses, vaccine brands, infertility history, occupation and geographic region also indicated no effect of vaccination on fertility.
While COVID-19 infection was not strongly associated with fertility, men who tested positive for COVID within 60 days of a given cycle had reduced fertility compared to men who never tested positive. did not, or men who had tested positive at least 60 days earlier. This data supported previous research that has linked COVID-19 infection in men with poor sperm quality and other fertility disabilities.
Senior author Dr Lauren Wise, Professor of Epidemiology at BUSPH, said: “These data provide reassuring evidence that covid vaccination in either partner does not affect fertility among couples trying to conceive. ”
“Prospective study design, large sample size, and geographically heterogeneous study population are strengths of the study, as we controlled for multiple variables such as age, socioeconomic status, pre-existing health conditions, occupation, and stress levels, ” He said.
The new data also helps address concerns about COVID-19 vaccines and fertility that have arisen from anecdotal reports of women experiencing changes in their menstrual cycle after vaccination.