Canadian researchers are reporting that COVID-19 may have a more damaging effect than previously thought.
The notable finding is that patients with mild-to-moderate cases of the virus who are not hospitalized have difficulties with mobility and physical functioning, according to first author Marla Beauchamp, PhD, School of Rehabilitation Science, Faculty of Health Sciences, Labourg. Center for Mobility in Aging, and the McMaster Institute for Research on Aging, at McMaster University in Hamilton, Ontario, Canada.
This finding underscores the need to develop and implement effective interventions and management to determine the effects of the virus over the long term and to address persistent deficits in mobility and functioning in this patient population, she and her colleagues said in their study. emphasized in the report. jama network open,1
Group study of COVID-19 effects
Beauchamp and colleagues analyzed data from the Canadian Longitudinal Study on Aging (CLSA) COVID-19 Study, which began in April 2020, and pre-pandemic data from the first CLSA from 2015 to 2018. Patients completed the exit questionnaire between September and December 2020. Participants were middle-aged and older individuals (>50 years) who lived in Canadian communities. The main outcome measure was the change in dynamics since the start of the COVID-19 pandemic in the exit interviews. The data was analyzed from February 2021 to May 2021.
An analysis of this population-based cohort study, which included more than 24,000 people who were 65 years of age or older, found that among 2748 individuals who had confirmed, probable, or suspected COVID- 19,113 (94.2%) were not hospitalized.
“Persons with confirmed or probable COVID-19 were more likely to have deteriorating mobility in terms of ability to engage in household activity (odds ratio) [OR], 1.89; with 95% confidence interval [CI], 1.11–3.22), physical activity (OR, 1.91; 95% CI, 1.32–2.76), and standing after sitting in a chair (OR, 2.33; 95% CI, 1.06–5.11) in adults without COVID-19 compared to during the same pandemic period,” the investigators reported.
In patients with suspected cases of COVID-19, the findings were similar (eg, household activity OR, 2.09; 95% CI, 1.82–2.41).
The investigators concluded, “This cohort study among older adults in Canada found that receiving a COVID-19 diagnosis was associated with worse mobility and functioning outcomes even in the absence of hospitalization. These findings suggest that that intervention may be needed for persons with mild to moderate COVID-19 who do not require hospitalization.”
1. Beauchamp MK, Joshi D, McMillan J, et al. Assessment of functional mobility after COVID-19 in adults 50 years of age or older in the Canadian Longitudinal Study on Aging. JAMA Net Open 2022;5(1):e2146168. doi:0.1001/jamanetworkopen.2021.46168