Tuesday, February 7, 2023

Diabetes, obesity and the microbiota: they are looking for volunteers for a study that will test the effects of two diets

The role played by the intestinal microbiota in people’s health is an issue that increasingly pervades the global scientific-medical community. And Argentina is no exception: a study led by CONICET researchers is looking for people with type 2 diabetes, prediabetes, obesity and healthy volunteers to evaluate how the microbes living in the digestive tract behave when dietary changes are made.

“A study of this magnitude It is unique in Argentina and Latin America., And globally we are one of the best done in this area”, he explains Bugle Juan Pablo Bustamante, principal investigator of the microbe study.

“It is unique in that it integrates several aspects and fields that complement each other: nutrition, approaches to metabolic disorders (obesity, diabetes and pre-diabetes), and something super novel, the study of the microbiota, on which more and more investigation“, expands Bustamante, CONICET researcher at the Institute for Research and Development in Bioengineering and Bioinformatics of the National University of Entre Ríos (UNER), and professor and researcher at the Faculty of Engineering of the University of Australia.

National statistics reflect the close relationship noted by the researcher. Excess weight (overweight and obesity) and diabetes are prevalent in Argentina, driven by poor diet and sedentary lifestyles. quick climb: They affect more than 60% and about 13% of the adult population, respectively.

“The approach to these diseases involves management different from the approach diet and physical activitySince diet significantly influences metabolism through the microbiota”, explains Gustavo Frechtel, CONICET clinical researcher and head of the nutrition department at the Hospital de Clínicas of the Faculty of Medicine of the UBA, where the study is carried out.

As a result, Bustamante and Frechtel (who also heads the Diabetes and Metabolism Laboratory of the Institute of Immunology, Genetics and Metabolism) worked on a trial design that would try to test that in volunteers who make dietary changes. are associated with modifications in the microbiota and, in turn, with improvements in health parameters.

On the one hand, they will identify microbes (bacteria, viruses, fungi and more that live in the gut), “but at the same time we will study the microbiomeWhich is the functional part, that is, we’re not just going to stick with the names and surnames of each microbe, but we’re going to learn what they’re doing inside our bodies and how we relate that to stages of health. or, in this case, of the disease”, says Bustamante.


A “Disruptive” Study

For Bustamante, it’s a “very disruptive” study. the reason? “We propose that through lifestyle therapy (diet and physical activity) health can be improved and in some cases even reversed in cases of type 2 diabetes.”

Reversal (some professionals prefer the term “reversion”) means, according to the investigator, that the person presents General Clinical Parameters For more than six months, as established by the American Diabetes Association (ADA).

Part Of A Team Working On The Processing Of Fecal Matter Origin Test Samples For Microbiota And Microbiome Analysis.  Photo Courtesy Microbar.

Part of a team working on the processing of fecal matter origin test samples for microbiota and microbiome analysis. Photo courtesy MicroBAR.

who can participate

The search is aimed at people between 30 and 60 years with obesity, prediabetes (higher than normal blood glucose levels) or newly diagnosed type 2 diabetes (under 6 years), preferably without treatment, who live in buenos aires (Because they must go to the control room of the Hospital de Clínicas). Also, healthy people of the same age who would form the control group.

people who are taking drugs (such as metformin) they shouldn’t leave themBut those who require insulin cannot participate.

Overall, you need to recruit 480 volunteers: 120 for each group (healthy or control, obese, diabetic and pre-diabetic).

800 people have already signed up, out of which 130 have passed the first stage. “Many will live and others will not, because Inclusion and Exclusion Criteria This ensures the scientific robustness of the study”, comments Bustamante, which is why they continue in an active search. Clinical recruitment and the first phase of the intervention will begin in the first week of May, he estimated.

All volunteers who pass the pre-selection process and are recruited for the study will be taken after signing the informed consent blood and stool samples and complete a food log and other forms related to physical activity and sleep for the past week.

At that point, the participation of the healthy volunteers or people making up the group of controls would end.

The remaining 360 will be assigned a graduate meal plan to follow: this may be one based on the ADA’s recommendations or plant based (Food plan 100% vegetable origin). in either case they will have a individual monitoring for two years And periodic blood and stool samples will be taken.

More And More Studies Focus On The Link Between Microbiota And Health.  Photo Shutterstock.

More and more studies focus on the link between microbiota and health. Photo shutterstock.

“The preparation of the meal plan and the follow-up of each individual shall be in charge of a professional expert in nutrition who Guiding the individual in food selection To control the portions and the frequency of consumption of each”, explains nutritionist Natalia Presner, who will be in charge of the patients enrolled in the traditional food intervention group.

“We’ve also designed workshops so that people who are involved in clinical trials learn and execute your plans Meal. So that they can know how to take control of their health and have equipment that will support them for the rest of their lives.”

Volunteers can “drop out” of the study at any time. Since adherence demands commitment, each volunteer will have a personal follow-up with a nutritionist and doctor who will guide and advise them “to the point of explaining how they can assemble their recipes, give them Offer dishes and support them in any way,” says Bustamante.

Volunteers Will Receive Personal Follow-Up From Doctors And Nutritionists.  Clinic Hospital.  Photo Courtesy Microbar.

Volunteers will receive personal follow-up from doctors and nutritionists. Clinic Hospital. Photo courtesy MicroBAR.

“We’re going to work closely with the participants, because we want to study the effect of a better adhesion for this type of diet, which we believe can significantly improve people’s health,” he stressed.

confirmed by the team over 80 professionals From various fields: nutrition, diabetology, cardiology, bioinformatics, biotechnology, biostatistics, molecular biology, among others.

The project is funded by CONICET and the University of Australia. In addition, it has two large donations from US companies (Illumina and Zymo Research) of reagents and kits for processing and analyzing fecal matter samples to analyze the microbiota and microbiome.

For inquiries and registration: www.microbiar.com

see also

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