Modern medicine offers “peel-and-paste” solutions such as nicotine or contraceptive patches that you can put right on your skin without visiting a doctor for an injection or procedure. Now, researchers have found that applying a topical ointment containing antitumor factor can increase the effectiveness of cancer treatment.
In a study that will be published soon in Molecular Therapy Oncolyticsresearchers from Tokyo Medical and Dental University (TMDU) reveal that the treatment of oral cancer cells with miR-634a microRNA targeting pro-tumor factors may increase the efficacy of cisplatin treatment.
More than 90% of cases of oral cancer are a type of cancer called oral squamous cell carcinoma (OSCC). While OSCC can be treated with chemotherapy and radiation, many patients develop resistance to cisplatin, the main drug used to treat it.
“We found it recently miR-634 against some cell-protective processes, such as anti-apoptotic signaling and antioxidant clearance, which are activated in cancer cells that are resistant to cisplatin, “says Phuong Xuan Tran, lead author of the study.” This suggests that increasing the amount of this small molecules in cells can increase their sensitivity to this drug. “
To test whether miR-634 can help increase tumor sensitivity to cisplatin, the researchers treated two different OSCC cell lines with both the miRNA and the drug and looked at how many of the cells survived.
“The results were very clear,” said Johji Inazawa, senior author of the study. “Treatment with miR-634 effectively increased cisplatin-induced cytotoxicity and overcame cisplatin resistance in OSCC cells, leading to increased tumor cell killing.
To confirm these results, the researchers then tested the treatment combination in mice with experimental tumors. When the mice were injected with cisplatin and a miR-634 ointment was applied to the tumors, the tumors shrank rapidly.
“Our findings indicate that miR-634“Mediated suppression of pro-tumor factors can effectively increase the sensitivity of OSCC to existing chemotherapeutic options such as cisplatin,” says Tran.
In summary, the results of this study indicate that miR-634 ointment may be helpful in enhancing the effects of chemotherapy in patients with advanced OSCC. Given that the synergistic effects of miR-634 and cisplatin has also been seen in esophageal carcinoma, bladder cancer and ovarian cancer cell lines, this treatment combination can also be effective across a variety of cancer types.
Material provided by Tokyo Medical and Dental University. Note: Content can be edited for style and length.