Friday, January 27, 2023

Ending nausea and vomiting: A toxin could help create a drug for cancer patients treated with chemotherapy

What causes nausea or vomiting in humans? The human body has different defense mechanisms, such as vomiting or fever, which are the result of various agents that can disturb people’s health.

From pregnancy to food allergies to stomach and intestinal infections, nausea is the order of the day. And, on many occasions, as is the case with food poisoning, they are the main solution to an illness that can be complicated.

Certain drugs or treatments, such as chemotherapy in cancer patients, can cause a person to have persistent nausea, a fact that can lead to a significant decline in the quality of life of these patients.

Therefore, researchers are still looking for the formula. Nausea disappears in patients treated with chemotherapyOne of the most aggressive technologies for the human body.

Luckily, one team has been published in the prestigious journal the cell A new study that analyzes different treatments to end nausea, although currently tested with rats, are unable to vomit due to their long esophagus and weak muscle strength.

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To see how nausea can be avoided, at least in these animals, The team treated rodents with staphylococcal enterotoxin A (SEA).produced by bacteria staphylococcus aureusBehind many food poisonings.

The team has been able to verify Rats with this substance opened their mouths at a greater angle than rodents given saline solution, Thus, the diaphragm and abdominal muscles of the animal contract simultaneously.

This pattern can be seen when the dog is about to vomit.

“The neural mechanism of retching is similar to vomiting,” Peng Cao, the paper’s author, explained in a statement from the National Institute of Biological Sciences in Beijing, China. “In this experiment, we successfully created a paradigm for studying toxin-induced retching in mice, with which we can look at the brain’s defensive responses to toxins at the molecular and cellular level.”

Thus, they have discovered This administered toxin releases serotoninA neurotransmitter that binds to other vagal receptors located in the gut – the gut is known as the second brain for a reason – and that communicates with other neurons in the dorsal vagal complex, Tac1+ DVC neurons.

When the team disabled these neurons, Sea-treated rats retreated less, compared to rats with normal neural activities. In short, an achievement that could have a positive impact on new drugs for people with cancer.

“With this study, we can now better understand the molecular and cellular mechanisms of nausea and vomiting, which will help us develop better drugs,” Cao said.

Nation World News Desk
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