Tuesday, February 7, 2023

Gold and cerium nanoparticles against type 2 diabetes

Scientists have evaluated the antioxidant and anti-inflammatory actions of gold and cerium nanoparticles in patients with type 2 diabetes.

The study shows that gold and cerium (Au/CeO2) nanoparticles with only 0.82% gold content exert antioxidant and anti-inflammatory actions on leukocyte-endothelium interaction of patients with type 2 diabetes. Thus, a protective role is created. Atherosclerosis and the presence of heart diseases.

This work has been carried out by the INCLIVA Health Research Institute of the Clinical Hospital of Valencia, the University of Valencia (UV), the Foundation for the Promotion of Health and Biomedical Research of the Valencian Community (Fisabio), the University Hospital Doctor. Peset and the Polytechnic University of Valencia (UPV) in collaboration with the Center for Networked Biomedical Research (CIBER) in Spain.

Leukocyte-endothelium interactions are a series of processes that occur when leukocytes, also known as white blood cells, move through the endothelial layer that lines blood vessels in search of sites of inflammation or infection. Huh. These interactions are an essential part of the immune system and play an important role in protecting the body from infection and disease.

The aim of this study was to evaluate the effects of gold and cerium nanoparticles (Au/CeO2) with different degrees of gold purity (10, 4.4, 1.79 and 0.82%) on leukocyte-endothelium and inflammation in patients with type 2 diabetes. Its principal investigator is Víctor Manuel Víctor González, a member of the Biomedical Research Center for Liver and Digestive Diseases Network (CIBEREHD) and the INCLIVA Vascular Function Research Group (coordinated by Dr. José María Villa Salinas), as well as the Group Underlying. Molecular Mechanisms in Diabetes of Fisabio in collaboration with Doctor Peset Hospital.

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Research team member. (Photo: CIBER)

The prospective and observational study was performed in a cohort of 57 patients with type 2 diabetes (cared for at the endocrinology service of the Doctor Peset University Hospital in Valencia and diagnosed according to the criteria of the American Diabetes Association) and 51 healthy people.

Among others, Susana Rovira-Lopis from UV; Hermenegildo García from the Institute of Chemical Technology (ITQ), a joint center of the Polytechnic University of Valencia (UPV) and the Higher Council for Scientific Research (CSIC); and Pedro Diaz Pozo and Milagros Rocha Barajas, both from the Fisabio-Hospital Doctor Peset. Participating research staff are affiliated with CIBER’s Liver and Digestive Diseases Section (CIBEREHD) as well as the Bioengineering, Biomaterials and Nanomedicine Section (CIBERBBN).

Type 2 diabetes is a serious health problem worldwide, as its prevalence is increasing and this means reduced life expectancy.

Oxidative stress and mitochondrial impairment have been linked to the development of insulin resistance, type 2 diabetes and cardiometabolic diseases. Oxidative stress occurs when there is an imbalance between the production of free radicals and the body’s ability to fight them with antioxidants. It causes health problems, such as premature aging, heart disease, certain types of cancer, and other chronic diseases.

The use of nanoparticles in biomedicine is increasing, with a wide variety of potential applications including antioxidant therapy, bioimaging and drug delivery. Among the various types of nanoparticles, cerium (CeO) nanoparticles are particularly promising because of their versatility, biocompatibility, and physico-chemical properties.

Additionally, CeO2 has been shown to have antioxidant properties and can be used to combat oxidative stress. This antioxidant capacity can be enhanced when the nanoparticles are combined with certain metals such as silver, platinum or gold. To obtain maximum antioxidant activity, gold nanoparticles need to be with a diameter of a few nanometers, with a narrow size distribution, and stable against agglomeration. This is achieved by precisely depositing gold particles onto a surface of cerium oxide that serves as a support. For this reason, the work is multifaceted and requires a team capable of producing this type of material such as ITQ.

Although the etiology of insulin resistance and type 2 diabetes is complex, various studies supported the potential of gold nanoparticles as antioxidants in models of type 2 diabetes, but whether they can provide benefits to people living with the disease remains unclear.

The title of this study is “Gold nanoparticles supported on ceria nanoparticles modulate leukocyte-endothelium cell interaction and inflammation in type 2 diabetes”. And it has been published in the Academic Journal Antioxidants. (Source: CIBER)

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