Friday, January 27, 2023

Gut bacteria may be important in diabetes

  • According to Statista, as of February 4, 2022, it was estimated that approximately 14.1 million adults in Mexico suffer from diabetes.

  • In the United States, healthcare spending for the treatment of diabetes is estimated to be approximately $380 billion in 2021.

  • In 2021, French Polynesia had the highest prevalence of diabetes in the world, with approximately 27% of the population suffering from the disease.

Some types of gut bacteria may contribute to the development of type 2 diabetes, while others may protect against the disease, according to the first results of an ongoing prospective study led by Cedars-Sinai researchers.

The study, published in the journal Diabetes, found that people with higher levels of a bacterium called Coprococcus had higher insulin sensitivity, while those with higher levels of the bacterial flavoni factor in their microbiome had higher insulin sensitivity. ,

Studies have also found that people who do not process insulin properly have lower levels of a certain type of bacteria that produces a type of fatty acid called butyrate.

Mark Gudarzzi, MD, PhD, director of Cedars-Sinai’s Endocrine Genetics Laboratory, is leading an ongoing study that is following people at risk for diabetes and looking at whether those with low levels of gut bacteria may be more likely to develop diabetes. people develop diabetes.

“The big question we hope to address: Do differences in the microbiome cause diabetes, or does diabetes cause differences in the microbiome?” said Gudarji, lead author of the study and principal investigator of a multicenter study called the Microbiome and Insulin Longitudinal Evaluation Study (MILES).

Researchers involved in MILES have been collecting data since 2018 from participating black and non-Hispanic white adults between the ages of 40 and 80. An earlier cohort study of the MILES trial found that cesarean delivery is associated with an increased risk of developing prediabetes and diabetes.

For the most recent study to emerge from this ongoing trial, researchers analyzed data from 352 people who did not have known diabetes who were recruited from Wake Forest Baptist Health System in Winston-Salem, North Carolina.

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