Thursday, December 08, 2022

High blood fat more harmful than previously thought

A new study finds that increased levels of blood fats in people with type 2 diabetes and obesity are more harmful than previously thought.

In patients with metabolic diseases, elevated levels of fat in the blood cause tension in muscle cells – a response to changes outside the cell that damage their structure and function.

Researchers from the University of Leeds have found that these stressed cells give a signal that can be transmitted to other cells.

The signals known as ceramides may have a protective benefit in the short term, as they are part of a mechanism designed to reduce stress in the cell. But in metabolic diseases, which are long-term conditions, signals can kill cells, making symptoms more severe and making the disease worse.

Increased fat in the blood has long been known to damage tissues and organs, contributing to the development of cardiovascular and metabolic diseases, including type 2 diabetes. This condition may be due to obesity, the rate of which has nearly tripled worldwide since 1975. In 2016, more than 650 million adults aged 18 and older were obese.

Research Supervisor Lee Roberts, Professor of Molecular Physiology and Metabolism at the University of Leeds School of Medicine, said: “While this research is at an early stage, our discovery could form the basis for new treatments or therapeutic approaches to prevent the development of cardiovascular and obesity. Metabolic diseases such as diabetes in people with high blood fat.”

In the lab, the team replicated the blood fat levels seen in humans with metabolic disease by exposing skeletal muscle cells to a fatty acid called palmitate. The cells began to transmit the ceramide signal.

When these cells were mixed with others that had not previously been exposed to fat, the researchers found that they communicated with each other, transporting the signal in packages called extracellular vesicles.

The experiment was reproduced in human volunteers with metabolic diseases and gave comparable results. The findings provide an entirely new angle on how we respond to stress, with important consequences for our understanding of some metabolic diseases, including obesity.

Professor Roberts said: “This research gives us a novel perspective on how stress develops in the cells of obese individuals, and provides new avenues to consider in developing new treatments for metabolic diseases.

“With obesity an ever-increasing epidemic, the burden of chronic disease such as type 2 diabetes necessitates new treatments. We hope that the results of our research may help address this growing concern as a new avenue for research.” Will open.”

The paper titled ‘Long-chain ceramides are cell non-autonomous signals that link lipotoxicity to endoplasmic reticulum stress in skeletal muscle’ is published today. nature communication.

The international research team included collaborators from the University of Cambridge, the University of Bonn, the University of Bari, Imperial College and AstraZeneca.

Story Source:

material provided by University of Leeds, Note: Content can be edited for style and length.

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