A study from the University of Coimbra (Portugal) showed that caffeine, polyphenols and other natural products present in coffee can reduce the severity of non-alcoholic fatty liver disease (NAFLD) in overweight people with diabetes type 2 (DMT2). can help.
Nonalcoholic fatty liver is a collective term for liver disorders caused by a build-up of fat in the liver. They can cause liver fibrosis, which can progress to cirrhosis (scarring of the liver) and liver cancer. NAFLD is not a result of excessive alcohol consumption but rather a result of unhealthy lifestyle, low exercise and high-calorie diet.
Study participants with higher coffee consumption had healthier livers. Those with higher levels of caffeine were less likely to have liver fibrosis, while higher levels of non-caffeinated coffee components were significantly associated with lower fatty liver index scores.
The study, published in the scientific journal ‘Nutrients’, suggests that in overweight patients with type 2 diabetes, increased coffee consumption is associated with less severe non-alcoholic fatty liver disease.
The researchers surveyed 156 borderline obese middle-aged participants about their coffee consumption, 98 of whom had type 2 diabetes, and provided 24-hour urine samples.
They were used to measure caffeine and non-caffeine metabolites, ie the natural products of the breakdown of coffee by the body. This method follows the recent shift towards urinalysis, rather than self-reported consumption, to obtain more defined quantitative data on coffee intake.
Caffeine intake is associated with a reduction in liver fibrosis in NAFLD and other chronic liver diseases. Other components of coffee, including polyphenols, have been suggested to reduce oxidative stress in the liver, reduce the risk of fibrosis, and improve glucose homeostasis in both healthy and overweight subjects. All these factors can also reduce the severity of type 2 diabetes.
“Due to changes in modern diet and lifestyle, obesity rates are rising and the incidence of both type 2 diabetes and non-alcoholic fatty liver disease is increasing, which may eventually become more serious and irreversible conditions that overwhelm health care systems.” Our research is the first to look at whether higher cumulative amounts of caffeine and non-caffeine metabolites in urine are associated with lower NAFLD severity in people who are overweight and have type 2 diabetes,” said study lead author Dr. said John Griffith Jones, principal investigator of the Center for Neuroscience and Cell Biology at the University of Coimbra.