Consuming a high-fat diet is associated with almost immediate weight gain. However, it doesn’t just focus on that aspect, as it also has negative effects on the body, promoting unhealthy cholesterol, diabetes, high blood pressure and heart disease.
A study by Australian and Chinese scientists warned, in an animal model (such as rats), that there is a link between a high-fat diet for 30 weeks and a subsequent decline in cognitive abilities. They also found the development of anxiety, depression and worsening of Alzheimer’s disease.
According to the work, which was published in the journal Metabolic Brain Disease, “mice with impaired cognitive function were also more likely to develop diabetes and gain weight because of brain changes caused by impaired metabolism.”
Led by UniSA neuroscientists Professor Xin-Fu Zhou and Associate Professor Larisa Bobrovskaya, the scientists highlight that these data add to the scientific evidence that is growing daily on the relationship between chronic obesity and diabetes with Alzheimer’s disease, a pathology that is projected to reach 100 million cases by 2050.
In Bobrovskaya’s words, “Obesity and diabetes affect the central nervous system, exacerbating psychiatric disorders and cognitive decline. And we demonstrated this in our study with rats. So this work made it clear that fatty diets Not only does it promote weight gain, but also creates neurological problems.
In the study, researchers randomly assigned mice to a standard or high-fat diet for 30 weeks, beginning when the animals were eight weeks old. Food intake, body weight and glucose levels were monitored at various intervals, along with tests for glucose and insulin tolerance and cognitive dysfunction.
“The mice on the high-fat diet gained a lot of weight, developed insulin resistance and began to behave abnormally compared to those fed the standard diet,” the scientists said.
In addition, the researchers analyzed behavior in mice that had been genetically modified to develop Alzheimer’s disease. In this group, the experts observed significant declines in cognition and pathological changes in the brain as they were fed the high-fat diet.
That’s why Bobrovskaya said that while “obese people have a 55 percent increased risk of developing depression, diabetes will double that risk.”
“Our findings underscore the importance of the findings in addressing the global obesity epidemic. It is highly likely that the combination of obesity, age, and diabetes leads to decreased cognitive abilities, Alzheimer’s disease, and other mental health disorders,” the researchers conclude. Removed
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