How covid pandemic stress affects ovulation

Life disruptions and the stress of the COVID-19 pandemic caused ovulation disturbances with decreased duration or levels of progesterone, according to research being presented Sunday at ENDO 2022, the annual meeting of the Endocrine Society in Atlanta, Ga.

Ovulation disturbances without disruption of the menstrual cycle were first studied during epidemics.

Gerilyn C. Prior, MD, FRCPC, professor of endocrinology, said, “These silent ovulatory disturbances suggest that so many women who are not taking hormonal forms of birth control have experienced post-COVID-19 vaccination. Reported early or unexpected periods in days.” at the University of British Columbia in Vancouver, Canada.

Prior and colleagues compared two independent, similarly designed studies 13 years apart: the Menstrual Ovulation Study (MOS), which was conducted from 2006-2008 in a group of 301 women, and the MOS 2, which studied 112 women during the pandemic. Both studies included menstruating women aged 19–35 years who were not taking systemic or combined hormonal contraceptives.

The first MOS was used as a control to compare the experiences of the MOS2 cohort during the pandemic. All participants in both studies answered a comprehensive health, fertility and lifestyle questionnaire and were asked to keep a daily diary of their menstrual cycles and normal life experiences.

For MOS2, ovulation was documented using a validated quantitative basal temperature. Researchers will confirm MOS2 hormonal characteristics using salivary progesterone levels. For the MOS cohort, researchers assessed ovulation by measuring urinary progesterone levels.

Prior said about two in three women who took part in the study were not ovulating normally during COVID-19. Women experienced either short luteal phases, in which an egg was released without sufficient time from ovulation for pregnancy to occur, or anovulation, which means no egg was released at all.

In comparison, the MOS study found that only 10 percent of women experienced ovulatory disturbances. The MOS2 and MOS studies showed similar body weight, body mass index values, and length of menstrual cycle and flow. Thus, females in MOS2 showed no obvious signs of reproductive disruption.

An analysis of the Menstrual Cycle Diary © MOS 2 found significantly increased rates of anxiety, depression, hopelessness, (overall negative mood), external stress, sleep problems and headaches compared to MOS.

“By comparing the two studies, and in particular their daily diaries, we can deduce that the SARS-CoV2 pandemic caused the disruption of life mostly within regular menstrual cycles to cause silent ovulatory disturbances – providing a unique experiment of nature.” does,” Pryor said.

Pryor will speak at the Endocrine Society’s reproductive health news conference on Monday, June 13 at 9 a.m. Register at to view the news conference.

/public release. This material from the parent organization/author(s) may be of a periodic nature, edited for clarity, style and length. The views and opinions expressed are those of the author(s). View full here.


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