Researchers from the Immuno-Regulation Laboratory of the Gregorio Marañón General University Hospital have carried out a study to find the immunological response against the COVID-19 messenger RNA (mRNA) vaccine, which is available for sale. Pfizer and Moderna.
Although both humoral and cellular immunity contribute in the first weeks after vaccination, it is estimated that 45% of vaccinated with BNT162b2 (Pfizer) He had lost his protection against Sars-CoV-2 eight months after vaccination while in the church” immunized with variant 1273 (Modern) unless he had lost 12.5%.
Thus, the results of this study published in Biomedicine under the title ‘Cellular and Humoral Responses Followed for 8 Months after Vaccination with mRNABased Anti-SARS-CoV-2 Vaccines’ and presented at the 43rd Congress of the Spanish Society of Immunology indicate that Vaccines are not equal in providing long-term protection.
Conclusions of studies on immunity to Covid
In the work, published in Biomedicine with the title “Follow-up of Cellular and Humoral Responses for 8 months after Vaccination with mRNABased Anti-SARS-CoV-2 Vaccines”, the authors studied the specific response against SARS-CoV-2 in the cohort. of * 150 volunteers with no previous history of Covid-19staff from Gregorio Marañón Hospital.
They were made by eight-month follow-up of antibody levels IgG Anti-S and a specific cellular response against the S protein of SARS-CoV-2, after the administration of two doses of these vaccines.
Another result was revealed in various cohort strategies men older than 48 years and women younger than 48 years vaccinated with Moderna had superior immunity to the same cohort vaccinated with Pfizer.
Previously, other work directed by researchers Rafael Correa and Marjorie Pion, from the Immuno-Regulation Laboratory of the Gregorio Marañón Hospital, showed that the humoral and cellular immunity conferred by these vaccines reached high levels. first two weeks after the administration of the second dose.
But one of the main unknowns was about vaccination to know the duration of this period of immunity. Thus, in this work, the immunological behavior after eight months of receiving the vaccine is presented, although more studies are necessary to understand the development of this immunity and the need and effects of the supplementary dose.