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Monday, November 28, 2022

“If we know which exposure causes a disease, we can prevent it”

Just as genes and genomics have become key elements for research and development personalized medicineStudy of exosomes will be necessary to obtain novel diagnosis and treatment.

Although it sounds like a novelty, the term ‘exposure’ is not new. It was discovered in 2005 by molecular epidemiologist Christopher P. Wilde, to refer to all the risks a person receives over the course of their life and their interactions with chronic diseases. And it is not only the environment, but the diet we follow, the behavior and other processes.

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El Comercio talks with Dr. Constantino Lazaridis, a gastroenterologist and researcher personalized medicine From Mayo Clinic (Rochester, Minnesota), to learn more about how health care will change in less than a decade.

How much will health care change?

We look to the future about the health effects of exposure to these elements. Of course, this will be a different meditation. The patient will receive a box, collect samples from their own bio-specimen, use some instruments to measure them and the results will be analyzed on a digital platform, so that when they reach your consultation, they will be given diagnosis and therapy. Can go custom,

— How expensive will individual treatment be?

A major study is underway, sequencing the exomes of 100,000 patients. detect cancer early, We believe this type of study will result in savings, as these tests cost between US$200 and US$300 in the United States compared to other invasive procedures to detect whether it is cancer. Very cheap. Apart from this, these tests detect many other things.

“We need artificial intelligence to understand what the millions of data from a patient mean.”

— How do you know that studying exposure could be the key to designing the medicine of the future?

The key is that if we know What type of exposure contributes to disease onset, we can take preventive measures. For example, from smoking we know that there are chemicals that cause diseases. Through blood and urine samples, we can detect the presence of that chemical element or something that shouldn’t be exposed and we try to eliminate it from the bloodstream, using medicine, or by other means .

– How important is technology in this new health paradigm?

We need to do many tests, from the genome to the elements of the environment. We collect a lot of patient data, and for us, using artificial intelligence can better understand the amount of specific information we collect. 10 or 15 years ago a patient scored 100 data points; Today it can generate 100 million. that’s why technology is very important to us, because we cannot do the same analysis that we did then. We need artificial intelligence to understand what that data means.

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— Are there specific factors related to the number of cancer cases in Latin America?

In my opinion, what happens in Latin America is no different from other parts of the world. There may be differences, but common ones are exposure to the environment, what we breathe, what we touch, what we eat, what we have at home. The natural environment is also important. We don’t have enough evidence yet.

Is it necessary to do other kind of studies?

There are many exposures that we are not measuring. In epidemiological studies, questionnaires are answered and better data will be obtained by taking samples of blood, stool and other biological samples. When we have that information, we will be able to better understand the effect of exposure.

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