Friday, January 27, 2023

If You’re Not Motivated to Exercise, the Key May Be in the Microbiome

You haven’t exercised a bit for the whole year and you have set a goal to get yourself in shape for 2023. Although everyone who knows you knows very well that you will not be able to keep your promise: laziness and excuses They slay your body every time you show off wearing your tracksuit.

If, no matter how hard you try, you can’t connect with the game, it’s probably nobody’s fault lack of motivationSometimes. The reason for your apathy to sweat in your shirt is probably within you. Literally: in your guts.

A mouse study by scientists at the University of Pennsylvania Perelman School of Medicine, the results of which are published in natureconfirmed that the level of motivation to play sports can be related to gut microbes,

Why were rats used in this study?

These rodents show similar variation in walking performance as humans

The team led by Dr. Christoph Theis has discovered that genetics have nothing to do with which lab rats can run and have more endurance in a race. In this sense, The differentiating factor was the presence or absence of certain species of intestinal bacteria.,

gut-brain connection

To reach this conclusion, the researchers interpreted genome sequences, intestinal bacterial species, bloodstream metabolites and other data from genetically different mice. Then, the daily turns they voluntarily made of a wheel and how far they managed to go before getting tired were measured. Contrary to what one might think, gut bacteria were more relevant than genetics in performance.

J. Nicholas Betley, associate professor of biology at the University of Pennsylvania, was in charge of confirming this theory by giving mice broad-spectrum antibiotics to eradicate their intestinal bacteria. without bacterial presence, The performance of the runner rats was substantially halved,

“Taken together, these results demonstrate that the stomach plays an important role in the motivation to exercise. Strikingly, the motivation to exercise is not intrinsic to the brain, but is controlled by the gastrointestinal tract,” Christoph Thies agreed.

The bacteria that had the greatest impact on rodents’ performance were eubacterium oblong why coprococcus euactus, both produce metabolites known as fatty acid amides (FAA), which stimulates the receptors Endocannabinoids CB1 to the sensory neurons of the gut, which in turn connect to the brain via the spinal cord. how much more excitement, more dopamine, Therefore, this extra dose favored the rats to have a greater desire to continue running.

Since rats and humans have a similar endocannabinoid system, it is What is most likely the gut-brain connection of rats too exist in people, But it is not yet known. Thies’s summary is quite clear: “If we can confirm the presence of a similar pathway in humans, we may provide an effective way to increase people’s exercise levels to improve overall public health.”

it will be important so that sedentary people can start playing regularly, Furthermore, elite athletes can be made to perform even better.


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Nation World News Desk
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