Saturday, January 28, 2023

La Jornada: Gene variant linked to attention deficit hyperactivity disorder

Gene variant linked to attention deficit hyperactivity disorder

juan ibarra

Newspaper La Jornada
Wednesday, January 25, 2023, p. 2

A research team from the Department of Cellular Biology at the National Polytechnic Institute’s Center for Research and Advanced Studies (Synvestv) in collaboration with the University of Sherbrooke in Canada discovered an inherited genetic variation that contributes to the development of the deficit. Disorder attention span and hyperactivity disorder (ADHD).

The study, published in the journal molecular psychiatry, identified an association between the presence of the disorder and a gene called latrophilin-3 (Lphn3) that encodes an adhesion molecule (Lphn3), a receptor with many essential functions such as the formation of neuronal synapses, important for proper brain performance .

The hypothesis was evaluated by Ana Lilia Moreno Salinas, a doctoral student in Synovestv’s Department of Cell Biology. We analyzed four variants at the cellular level identified in the Lphn3 gene from patients with ADHD and compared them to a person who does not have these mutations to see if they affect its function.he pointed.

While the four variants identified in patients with the disorder were found to be different, they also interfere with receptor functions in the same way, suggesting the potential for the mutations to drive the development of the disorder.

The finding suggests that the mutation may lead to insufficient formation of neuronal synapses, resulting in a delay in the development of the nervous system, ultimately resulting in the expression of symptoms associated with the disease.

The disorder is largely associated with a genetic component as in many cases there is a history in the parents. The phenomenon may be due to the fact that the mutations are genetic. Although screening methods have been used to identify factors related to ADHD, the exact causes are still unknown.

Patients have some abnormalities in brain areas related to learning, attention and motor planning; This suggests defects in neural connections that reflect a delay in brain maturation.

In addition, it is one of the psychiatric disorders with the highest incidence in the child population, which manifests itself in attention deficit and impulsivity.

Epidemiological studies suggest that its worldwide prevalence is 3 to 5 percent among infants. In Mexico, it is estimated that more than 2 million adults and about 1.5 million children and adolescents suffer from it. Although it was officially recognized in 1968, in the official diagnostic manual of the American Psychiatric Association, its existence and persistence into adulthood is still debated.

Likewise, there is uncertainty in the method for its diagnosis, as diagnostic tools do not go beyond behavioral assessment, which in most cases leads to late detection.

It is important to continue studying Lphn3 because during neurodevelopment it provides signals for cells destined to form a network in the nervous system to connect with others and help with the correct functioning of synapses. During brain maturation, this molecule participates in the regulation of certain neurological processes related to learning and motor behavior, in the sense that the symptoms of the disorder may be related to its failure.

The study provides new information on the molecular mechanisms of the disorder and lays the foundation for the development of diagnostic methods based on specific biomarkers with the aim of establishing alternative treatment strategies.

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