In addition, scientists believe that weight loss interventions, such as bariatric surgery, “can damage our gut, which can create our fat cells, ultimately having a major impact on our health.” ”
What are endotoxins?
Endotoxins are components present within bacterial cell walls and released when they break down or decompose.
These toxins enter the bloodstream, which is how they reach fat cells and even some organs such as the liver, the latter is reviewed by ScienceDirect.
Now, The Guardian explains that, in a healthy gut, endotoxins are part of the life cycle of microbes that play an important role in human health.
However, in obese people, the intestinal barrier is more fragile and can leak, allowing endotoxins to leak out, enter the blood and other parts of the body.
Endotoxin and weight gain
In the new study, researchers evaluated 156 people, 63 of whom were obese. The scientific work also included people who had undergone bariatric surgery.
The scientists’ goal was to understand how endotoxins were involved in increasing the risk of obesity and type 2 diabetes.
To do this, the team collected blood and fat samples from the participants. Next, they examined white fat cells, which store energy, and brown fat cells, which use energy and are associated with metabolic activity.
They found, The Guardian says, that white fat cells obtained from obese people were less likely to turn into brown fat cells than fat cells from lean people.
According to the researchers, this is likely due to the higher levels of endotoxin found in the blood of the obese participants.
Additionally, the team found that bariatric surgery reduced the amount of endotoxin in participants’ blood, and this was associated with improved metabolic health of fat cells.
Lead researcher Professor Mark Christian, from Nottingham Trent University School of Science, explained: “Endotoxins from the gut reduce the metabolic activity of fat cells and reduce their ability to become ‘brown-like fat cells’, which can aid in weight loss. could.” technology.
“Our study highlights the importance of the gut and adipose tissue as interrelated critical organs that affect our metabolic health,” he added.
In conclusion, Trent added: “As such, this work suggests that the need to limit endotoxin-induced fat cell damage is even more important when overweight, as endotoxin contributes to the reduction of healthy cellular metabolism.”