Monday, August 8, 2022

Main medications often associated with headaches

Many of the drugs on the list were less likely to be associated with headaches.

The results cast doubt on the review mechanism for headache warnings on drugs. Photo: Shutterstock.com.

During the annual convention of the American Society HeadacheA group of researchers presented Medicine who are most related Headache after consumption.

These are monoclonal antibodies, antivirals, immunomodulators and pulmonary artery vasodilators, which top the list. Medicine Those were listed most frequently in the federal database of side effects as causes of headaches, to which one can contribute.

“The surprising findings included the significant amount of immunosuppressants and immunomodulators present in the data,” senior author Brett Musialowicz, a medical student at the Robert Wood Johnson School of Medicine, New Brunswick, New Jersey, said in an interview. “Furthermore, our data provide evidence that many Medicine who belong to these classes Medicine were less likely to be associated with headache induced by Medicine“, which raises doubts about the mechanism.

Medications Often Linked to Headaches

Researchers begin their study to better understand Headache as a side effect of using MedicineMusialowicz said. They analyzed entries from the Food Administration Adverse Event Reporting System and medicines for the period from July 2018 to March 2020 and 30. listed to Medicine Headaches are commonly reported and related to their reported odds ratio (ROR).

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According to a website dedicated to pharmacovigilance training, ROR “refers to the odds of an event occurring with your drug compared to the odds of the same event occurring with all other drugs.” Medicine in the database”.

After consolidating generic and brand-name data, the drug most commonly associated with headache was apremilast with 8,672 reports, followed by adalimumab (5,357), tofacitinib (4,276), fingolimod (4,123), and etanercept (4,111). These Medicine Treat autoimmune disorders such as psoriasis, multiple sclerosis, and Crohn’s disease

other people MedicineOut of the top 15, by frequency, treatments for hepatitis C are (4 Medicine), pulmonary arterial hypertension (4) Medicine), arthritis (1 drug), and asthma (1 drug).

30’s Medicine A drug often associated with headache, epoprostenol, a drug for pulmonary hypertension, had the highest ROR at 12.8, ranked 23rd. was the next highest Medicine Against hepatitis C glecaprevir and pibrantasvir, ranked tenth in the frequency analysis and both tied with an ROR of 9.4.

Pulmonary artery dilators and vasodilators are known to cause headaches by sensitizing the extracranial arteries. Clinical evidence suggests that there is some type of vascular component. HeadacheMusialowicz said.

“It is suggested that monoclonal antibodies cause Headache through an immune response. Several monoclonal antibodies are in receptor-directed trials [del péptido relacionado con el gen de la calcitonina], which is believed to be involved in migraine. These tests will help to further elucidate the mechanism Headache You Medicine ability to treat these conditions.

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Is the data useful?

Stewart Tepper, a neurologist at the Geisel School of Medicine in Dartmouth, Hanover, New Hampshire, who is familiar with the study’s findings, dismissed the new research in an interview. He notes that any member of the public can contribute to the federal database of adverse effects (manufacturers) Medicine need to contribute), and the data says nothing about the denominator.

“It’s not a proper way to assess adverse effects, for everyone and their uncles to say, ‘This particular drug did this to me. It’s not helpful in any way,'” he said. However, he added that the database sometimes “gives you a little hint so you can go back and try to get the scientifically aggregated data.”

When asked to respond, co-author and neurologist Pengfei (Phil) Zhang, MD, of the Robert Wood Johnson School of Medicine, said the FDA created the database “for a reason.” They also noted that the researchers used a statistical analysis technique, RoR, which was invented to adjust for vulnerabilities in the database.

Source consulted here.

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