Researchers from the University of Cadiz and the University of Granada have discovered that Diabetes favors soluble forms of amyloid beta, which are particularly toxic and damaging to neuronal tissue.
Amyloid beta peptide deposition in a combined model of Alzheimer’s disease and diabetes provides details of the process. A new therapeutic target to work on to slow or stop the progression of this dementia, It is one of the main ways to explore the future.
In recent years it has been recognized Diabetes and prediabetes as risk factors for dementia, but the mechanisms mediating this relationship are not fully known. The work elucidates one of the ways in which type 2 diabetes mellitus, or its earlier stage, prediabetes, They contribute to cognitive decline and accelerate the progression of Alzheimer’s disease.
Specifically, the study describes a new development of beta amyloid pathology in Alzheimer’s patients who also suffer from prediabetes or type 2 diabetes. Based on the novelty of the results obtained Finding a distinct progression of amyloid beta pathology when encountered only in Alzheimer’s disease and a second development when this dementia is accompanied by type 2 diabetes or prediabetes, In the combined model, a greater accumulation of beta amyloid peptide is seen at the vascular level, known as beta-amyloid angiopathy.
Furthermore, diabetes favors soluble forms of the amyloid beta peptide, which are the most toxic and damaging to neuronal tissue. Said modification of beta-amyloid pathology Increases oxidative stress at the neuronal and vascular level, all this Facilitates rupture of blood vessels in the brain and increases neuronal death typical of Alzheimer’s disease.
In vivo multiphoton microscopy, the principal technique of study
research has been developed thanks to a Refined multiphoton microscopy techniques in living organismswhich allows monitoring on a single animal and on a brain pathology over time, “It reduces the number of animals needed in research, certainly a huge advantage over more rudimentary techniques, which triple the number of animals needed to do an equivalent study“, elaborated the UGR professor. Juan Jose Ramos.
In vivo multiphoton microscopy is a technique within reach of some laboratories, able to offer data and images that could not be achieved with other techniques. “The next question we ask ourselves: controlling diabetic pathology, Can we control or reduce the progression of beta-amyloid disease and its consequences?“, the expert decided.