Thursday, February 2, 2023

Metformin reduces need for joint replacement in type 2 diabetes

Results from a new observational study of more than 40,000 people suggest that use of metformin reduces the risk of needing knee or hip replacement surgery by 39 and 29%, respectively. This benefit was persistent, regardless of the severity of diabetes…

Results from a new observational study of more than 40,000 people suggest that use of metformin reduces the risk of needing knee or hip replacement surgery by 39 and 29%, respectively. This benefit was persistent regardless of the severity of diabetes, hypertension, overweight, or the presence of rheumatoid arthritis, as well as the use of analgesics or other antidiabetic mediations.

Changhai Ding, a researcher at Guangzhou Southern Medical University and director of the study, says that Type 2 diabetes (T2D) is considered a risk factor for osteoarthritis, even in normal-weight individuals., The widespread use of metformin in T2D worldwide for decades has contributed to establishing its safety profile, say scientists, in addition to the fact that it is associated with a reduction in several risks, such as cardiovascular, inflammatory pathology and any cause death rate from Although previous observational studies on the drug’s benefit in osteoarthritis have not been conclusive, existing preclinical data support its potential chondroprotective role. Indeed, administered immediately after induction of a joint lesion, metformin delays the onset of osteoarthritis, whereas its intragastric or intraarticular administration in other models of the disease reduces cartilage degradation and pain. Ding points out that metformin can be administered in doses of up to 2.5 grams daily without causing hypoglycemia or lactic acidosis in patients without diabetes, so he plans to conduct clinical trials aimed at establishing the drug’s efficacy in osteoarthritis. considers the development of


Nation World News Desk
Nation World News Deskhttps://nationworldnews.com
Nation World News is the fastest emerging news website covering all the latest news, world’s top stories, science news entertainment sports cricket’s latest discoveries, new technology gadgets, politics news, and more.
Latest news
Related news