A team of scientists has developed a drug administered through a nasal spray Able to enhance the brain’s natural mechanisms to prevent seizures and protect neurons in models of Alzheimer’s and epilepsy.
It is a peptide called A1R-CTIn an article published in Scientific Journal, as detailed by the authors associated with the Medical School of Georgia at Augusta University (United States) JCI Insights.
Promote the natural mechanism of the brain
The substance in question, they explain, appears to reduce the uncontrolled electrical activity in the brain that commonly manifests in more than half of people with traumatic brain damage, stroke, and Alzheimer’s. the fact that can be administered nasally It also enhances its potential as an anticonvulsant drug, for example to inhibit serial seizures.
More specifically, A1R-CT inhibits the production of neurabin, a protein that helps control the behavior of brain systems. curb hypersensitivity of neurons (seizure trigger) so that you don’t overdo it.
This same chemical pathway is involved in irregular heart rhythms, and in fact similar substances are used in injectable form to treat excessive heart rate.
Specifically, the scientists found that animal models (mice) with low levels of neurabin had fewer seizure episodes, were less severe, and They all survived. In contrast, people with normal neurabin levels experienced seizures lasting 30 minutes and died shortly thereafter in 10% of cases.
With these data in place, let’s move on to the next step. dose scan and ideal administration time, before the drug can enter the necessary clinical trials to approve its use in humans.
Saggu S, Chen Y, Chen L, Pizarro D, Pati S, Law WJ, McMahon L, Xiao K, Wang Q. A peptide blocking the ADORA1-neurabin interaction is anticonvulsant and prevents epilepsy in an Alzheimer’s model. JCI Insights. 2022 Jun 8;7(11):e155002. doi: 10.1172/jci.insight.155002. PMID: 35674133; PMCID: PMC9220929.