Navarre researchers want to predict cognitive decline of epilepsy patients

Navarre researchers want to predict cognitive decline of epilepsy patients

Epilepsy Unit of the University of Navarra Clinic has initiated a clinical study that attempts to establish biological markers that allow risk to be predicted Epilepsy patients develop a cognitive impairment associated with this disease,

It is estimated that between 60 and 70% of these people are epilepsy will suffer cognitive problems Particularly memory loss, the clinic said in a statement.

In this regard, Asier Gómez, specialist in the Department of Neurology at the Clínica Universidad de Navarra, explains that until a few years ago epilepsy treatment This included complete control of epileptic seizures, but they are observing that “most patients developed memory or attention problems that significantly limited their quality of life, sometimes due to epileptic seizures. “With even greater impact.”

This study, financed by the Carlos III Health Institute, dependent on the Ministry of Science and Innovation, seeks to investigate cognitive impairment associated with epilepsy Tau and beta amyloid proteins, similar to the biomarkers used for early diagnosis of Alzheimer’s disease.

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For detecting this cognitive impairment Three tests are performed: a complete cognitive assessment, sampling of cerebrospinal fluid through lumbar puncture and a specific brain MRI.

“With this process we intend to objectively determine whether cognitive problems Patients who refer to us belong to a Neurodegenerative processes associated with epilepsy or other factors, such as drugs. This progress will also allow us to intervene early to treat this cognitive alteration with tools such as cognitive rehabilitation,” he adds.

The study is currently open patients with temporal lobe epilepsy Whose age is between 40 to 70 years.

Some? Most frequent cognitive change Epilepsy causes difficulty remembering information, such as conversations or recent events, finding the right words, or slowness in completing tasks.

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All these complications can affect normal life cognitive disorders Causes are caused by a combination of several factors, such as the epileptic seizures themselves, the medications used to treat them, or mood disorders, he explains.

Experts say that the people most affected are usually the oldest people, many years older. Disease And higher frequency of seizures and hence, people who have been taking the drug for the longest time.

To prevent or reduce these deficits, cognitive rehabilitation is a therapeutic option focused on improve cognitive function In general and each of its areas in particular, such as memory, executive functions, attention, language and visuospatial functions.

“it rehabilitation It is designed with specific objectives tailored to each patient. Exercises are performed that strengthen the affected basic processes, so that the neural networks involved in the altered function can be retrained. In other cases, there are compensatory strategies aimed at helping the patient learn functional activities for their daily life, even if the altered function does not improve significantly,” says Teresa Rogoni, a neuropsychologist in the clinic’s neurology department.

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with Individualized Neuropsychological Rehabilitation Monitoring Each patient and their family make progress in managing the cognitive and behavioral changes and the impact on their daily life decreases.

According to Spanish Society of Neurology About 400,000 people are suffering epilepsy In Spain there are up to 22,000 new cases each year. In Europe, this neurological pathology affects approximately 6 million inhabitants.


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