Saturday, August 13, 2022

‘Nocebo effect’: Two-thirds of Covid jab reactions not due to vaccine, claims study

Researchers claim that more than two-thirds of the common side-effects experienced after the Covid jab can be attributed to a negative version of the placebo effect rather than the vaccine.

Scientists in the US examined data from 12 clinical trials of COVID vaccines and found that the “nocebo effect” accounted for about 76 percent of all common adverse reactions after the first dose and about 52 percent after the second dose.

The findings suggest that a large proportion of mild side-effects, such as headache, short-term fatigue, and arm pain, are not produced by components of the vaccine, but by other factors thought to produce a nocebo response, including anxiety, expectation. And wrongly attribute various diseases to being jab.

In view of their results, the researchers argue that better public information about nocebo reactions could improve the COVID vaccine by reducing the lingering concerns some people have.

“Telling patients that the intervention they are taking has side-effects that are similar to placebo treatment for the condition in randomized controlled trials actually reduces anxiety and prompts patients to consider a side-effect.” Give some time,” said Ted Kapchuk, professor of global health and social medicine at Harvard Medical School, and a senior author on the study. “But we need more research.”

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Professor Kapchuk and Dr Julia Haas at Beth Israel Deaconess Medical Center in Boston analyzed adverse events reported during a dozen clinical trials of COVID vaccines. In each trial, people on the placebo arm were given injections of an inactivated salt solution instead of the vaccine. The study did not look at serious, rare side effects such as blood clots or inflammation of the heart.

Writing in the journal JAMA Network Open, the researchers describe how more than 35 percent of those in the placebo groups experienced so-called “systemic” side effects, such as headache and fatigue, after the first injection, with 16 percent reporting the site. Specific diseases, including arm pain or redness or swelling at the injection site.

As expected, those who received their first shot of the vaccine were more likely to experience side-effects. About 46 percent reported systemic symptoms and two-thirds experienced arm pain or other localized symptoms at the injection site.

When the researchers looked at side effects after the second vaccine, they found that the rate of headache or other systemic symptoms was almost two times higher in the vaccine group than in the placebo group, 61 percent and 32 percent, respectively. The difference was even greater for local diseases, reaching 73 percent in those who had the vaccine and 12 percent in the placebo group.

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Overall, the researchers calculate that about two-thirds of the common side effects reported in COVID vaccine trials are driven by nocebo effects, in particular headache and fatigue, which are among the most common adverse reactions following a shot in many COVID vaccine leaflets. list as.

While evidence suggests that information about side-effects may cause people to misattribute common illnesses to the vaccine, or cause people to hyper-alert about how they are feeling, Kaptachuk side-effects Let’s argue for more information about, no less. “Most researchers argue that patients should be told less about side effects to reduce their anxiety,” he said. “I think this is wrong. Honesty is the way to go.” – Guardian News and Media

Nation World News Desk
Nation World News Desk
Nation World News is the fastest emerging news website covering all the latest news, world’s top stories, science news entertainment sports cricket’s latest discoveries, new technology gadgets, politics news, and more.
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