Tuesday, August 9, 2022

Polycystic ovary syndrome: comorbidity factors in women

Women with this disease are at risk of multiple morbidities and drug use at late childbearing age.

Women with PCOS at the age of 46 have an increased risk of T2DM, depression, migraine, hypertension, tendonitis, osteoarthritis. Photo: Shutterstock.

polycystic ovary syndromeO! drunker In its abbreviated form, it is the most frequently occurring endocrine disorder in women of reproductive age with a prevalence of 5% to 18%.

The current study focused on assessing morbidity, self-reported symptoms, drug use and health care service employment among 46-year-old women. drunker and without control drunker,

drunker was primarily considered a reproductive condition; However, it is now generally accepted that women with drunker are at higher risk for metabolic disorders including obesity, glucose intolerance, type 2 diabetes mellitus (T2D), metabolic syndrome and possibly cardiovascular events.

In addition, it has been shown that women with drunker They have a higher risk of psychological morbidity, 10, 11, asthma, 12, and migraine. 13

Surprisingly, only a few studies have systematically evaluated morbidity usually in women drunker,

This should be a high priority given the high cost to the society as a result of morbidity related to drunker, For example, it has been speculated that T2DM is related to drunker The UK alone carries an annual cost of £237 million ($310 million) in 15 and $1.77 billion in the US

It is often underdiagnosed and therefore under-represented in patient and national registries, thereby limiting the capture of comorbidities. Previous studies mainly reported hospital diagnoses with no data on symptoms. Furthermore, the focus has been primarily on women in their early or middle reproductive years, and morbidity data in the late childbearing years are sparse.

Material and methods

The study population came from the 1966 Northern Finland Birth Cohort and included women who reported and/or were diagnosed with amenorrhea and hirsutism at age 31 drunker controls at age 46 (n = 246) and without symptoms or diagnosis drunker (n = 1573), referred to as women without PCOS.

The main outcome measures were self-reported data on symptoms, diagnosed diseases, and use of medications and health care services at age 46.

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There was a 35% increase in overall morbidity risk and a 27% increase in drug use compared to women without drunkerAnd the risk remained after adjustment for body mass index.

Most common diagnosis in women drunker They were migraine, hypertension, tendinitis, osteoarthritis, fractures and endometriosis.

drunker It was also associated with autoimmune diseases and recurrent upper respiratory tract infections and symptoms. Interestingly, employment of health care services did not differ between the study groups after adjustment for body mass index.

Graphic: Intramed.

with women drunker They are fraught with multiple morbidities and drug use, regardless of body mass index.

This population-based follow-up study shows women at high risk of polymorbidity and poor self-reported health. drunker until the last breeding years.

we show that drunker is associated with an increased risk of several diseases and symptoms, some of them related for the first time drunker,

Some of the differences in disease risk and in particular drug use were attributable to higher BMI, indicating that drunker, per se, may not always be the main cause of some concomitant diseases. However, the average morbidity score for women drunker was similar to women with a BMI of 25 kg/m2 or more drunker and less weight.

More study needed on pathogenic mechanisms of comorbidities drunkerSince higher BMI alone does not seem to be responsible for the increase in morbidity.

at the age of 46, with women drunker There was an increased risk of T2DM, depression, migraine, hypertension, tendonitis, osteoarthritis (especially in the knee, back or shoulder), fractures, endometriosis, gestational diabetes and preeclampsia, although after adjustment, the risk of T2DM, depression, gestational diabetes, And there is no longer a significant increase in preeclampsia.

Tendonitis has not been linked to drunker before this; However, musculoskeletal disease and osteoarthritis in general are more common in affected women. Fracture risk in women drunker It is debatable. In a Danish population, fractures were not more common in the Taiwanese study as well, in contrast to ours.

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Recently, we have reported higher levels of vitamin D in the same population. drunker, However, there appears to be a decrease in markers of bone formation and bone mineral density. drunker, Further studies should be conducted among women with PCOS with different phenotypes to separate the role of hyperandrogenism and metabolic disorders.

Respiratory tract problems were more common in women drunker, Women reported wheezing cough, recurrent respiratory infections, and atopic, infantile, or allergic eczema more frequently than controls. Evidence of higher prevalence of various infections and respiratory diseases in women drunker is increasing.

The mechanisms behind these disorders are unknown, but increased low-grade systemic inflammation or hyperandrogenism may be predisposing factors.

The high prevalence of eczema is a novel finding, although some dermatological manifestations, such as hidradenitis suppurativa, have been previously associated with drunker,

This is the first study to assess self-reported symptoms related to infections and autoimmune diseases in women. drunker, Affected women reported more frequent recurrent infections, including pneumonia, ear infections, and the common cold, and a greater susceptibility to infection than controls at age 46.

In addition, symptoms related to autoimmune diseases were more common in women. drunker compared to controls. These results are supported by a recent systematic review and meta-analysis in which women presented drunker Not only with an increased risk of autoimmune thyroid disease, but also with an increased risk of asthma.

There is only one previous population-based study of drug use among women. drunker, Although the increase in drug use was self-reported in our study, the drug profile was similar to that reported in the Danish registry-based study. Drugs used to treat dietary tract and metabolic diseases were more frequently polycystic ovary syndrome,

with women drunker Reported morbidity, symptoms, and increased drug use more frequently than controls. In addition, with women drunker They rated their health as poor or very poor about three times more often than controls, in line with our previous finding.

Source consulted here.

Nation World News Desk
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