Rare gastric adenocarcinoma associated with signet ring cell adenocarcinoma of the pancreas found

The development of gastric cancer is a multifactorial process.

Signet ring cell carcinoma (SRC) is a poorly differentiated cancer of the stomach. Photo: Shutterstock.

Synchronous malignant neoplasms are primary cancers that are diagnosed within a 2-month period in an individual, and although they are rare, as reported by the medical literature, they affect only 2.4–8% of all cancer cases. and a lower number of simultaneous gastric and pancreatic cancer cases.

Currently, synchronous malignant neoplasms are more frequent

In cases of gastric carcinoma, however, there is a clinical case supporting that there are reports that support the coexistence of gastric and pancreatic cancer, albeit in a limited way, and they account for all cases of synchronous carcinoma only. representing 3.8%.

In fact, this type of pathology is even rarer when there are cases of synchronous adenocarcinoma of the pancreas and signet ring cells and gastric cancer, as documented in a recent clinical case.

And it is that a group of experts found a case where a diagnosis of pancreatic adenocarcinoma occurred. This was a 76-year-old female with a previously diagnosed intraductal papillary mucinous neoplasm (IPMN), who presented with abdominal pain on the left side.

During diagnosis, computed tomography and endoscopic ultrasound images with biopsy were performed, leading to a diagnosis of pancreatic adenocarcinoma.

From the month of diagnosis, the patient underwent a procedure and was found to be a gastric adenocarcinoma,

Physicians indicated that the patient began chemo-radiotherapy, however, after several hospitalizations, she was unable to tolerate further cancer treatment and the patient died.

For this reason, he stressed that, as some cases of synchronous malignancies involving the stomach and pancreas have been reported, it is important that biopsies be performed to aid early diagnosis in patients with a history of cancer.

“To our knowledge, only metachronous cases gastric adenocarcinoma and pancreatic SRC. Therefore, it represents the first case of the report gastric adenocarcinoma IPMN-associated synchronous CRS and pancreatic adenocarcinoma in the literature”, they highlight in the publication.

Mucinous-type adenocarcinoma is a rare form of undifferentiated gastric carcinoma. The clinical presentation is nonspecific, with dyspepsia being the most common symptom. The prognosis of this disease is poor because the diagnosis is usually late.

The development of gastric cancer is a multifactorial, complex and long-term process. Helicobacter pylori infection alone is unlikely to be responsible for the development of gastric cancer.

meanwhile, gastric adenocarcinoma It is a strange disease. Each histologic subtype may involve multiple molecular changes. Anatomic and histologic grading can provide insight into tumor biology.

On the other hand, signet ring cell carcinoma (SRC) is a poorly differentiated colon cancer. In general, poorly differentiated cancers are thought to show poor prognosis and aggressive behavior.

Access the case here.

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