Wednesday, December 07, 2022

Raw meat parasite linked to common eye disease

Raw Meat Parasite Linked To Common Eye Disease

Toxoplasma gondiia parasite closely associated with cats, is behind retinal scarring in one in 150 Australians, according to a new Flinders University analysis.

Many animals around the world are infected by the parasite, generally contracting the disease in environments soiled by infected cats or by consuming other infected animals. For humans, while domestic cat faeces can be a carrier, the most common route of infection is consumption of undercooked or raw meat sourced from infected livestock.

“Considering Australia’s substantial population of feral cats that are known to be infected, alongside high levels of farming and diets rich in meat, it’s imperative we understand the prevalence of the disease across the country,” said study senior author Professor Justine Smith, Strategic Professor in Eye & Vision Health at Flinders University.

Smith and her team analyzed retina photographs of over 5000 people living in the Busselton area in Western Australia, previously collected to evaluate the prevalence of glaucoma and age-related macular degeneration for a long-term healthy aging study.

Three specialized ophthalmologists, including Professor Smith, assessed the scans for toxoplasmic retinochoroiditis, with positive cases confirmed with antibody blood tests.

“Among the 5000 people, we found eight participants with blood test-confirmed toxoplasmic retinal scars. Add to that about three-quarters of the retinal lesions would be in a position not visible in these particular photographs, we were able to estimate the prevalence of ocular toxoplasmosis to be 1 per 149 persons,” he said.

“While there is no cure or vaccine, the symptoms of toxoplasmosis vary depending on the age, health and genetics of the infected individual. Many people are asymptomatic, but the most common disease that we see in the clinic is retinal inflammation and scarring known as ocular toxoplasmosis.

“Studies around the world show that 30% to 50% of the global population is infected with Toxoplasma, but despite knowing that, what we didn’t know was how common the related eye disease was,” Smith said.

The work claims to represent the first effort to quantify the rate of ocular toxoplasmosis in Australia, with the findings indicating the condition can be considered common. With previous research showing the infection can lead to reduced vision in more than 50% of eyes and even blindness, the authors say it is important for people to understand the risk factors of toxoplasmosis and ways to avoid it.

“While people are often familiar with pregnant women needing to avoid cat litter trays, we also need everyone to know that preparation of meat is an important risk factor,” Smith said.

Research by Smith in 2019 highlighted a high prevalence of Toxoplasma in Australian lamb sold in supermarkets.

“Add to that that it’s now becoming more common to prepare meat in and out of restaurants to be purposefully undercooked or raw, then the likelihood of people becoming infected with Toxoplasma increases.

“We need people to be aware this disease exists, so they can make informed decisions about how they prepare and eat their meet. The parasite can be killed easily by cooking the meat to an internal temperature of 66ºC (or medium) or by freezing it prior to cooking.”

The research follows on from a series of papers recently published by Smith and his team on the condition, including one that uses new technology retinal imaging to show the changes that occur in ocular toxoplasmosis at the tissue level, and another that highlights the best clinical practice for managing the disease.

Image caption: Eye scan showing ocular toxoplasmosis. Image credit: Associate Professor Joo M Furtado.


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