The CIBER-BBN team at the Institute of Bioengineering (IBEC) of Catalonia has developed a new breast cancer model which recreates the complexity of their creation Tumor. se is a ‘bioink’ made from pig breast tissue from which cells have been removed, and which serves as the basis for growth human cancer cells.
Work directed by the group’s principal investigator, Elizabeth Engel Cyber-BBN/IBEC The Biomaterials for Regenerative Medicine and Professor at the Polytechnic University of Catalonia (UPC) has been published in the scientific journal ‘ACS Appel’. Mother. interface’. Despite the high incidence of breast cancer, it remains a challenge for doctors and researchers, because of the great complexity of tumor tissue and the tumor “microenvironment”, making it very difficult to reproduce real conditions in the laboratory for study and treatment. Its difficult. ,
The team used female pig breast tissue, taking advantage of the great similarity between the genomes of pigs and humans, and it is a tissue that is easily and in large quantities obtained to regenerate the extracellular matrix that forms the microenvironment tumours. can go. through various processes Pig cells removed from breast tissue, leaving only the ECM. what they call biotinylatedis the one that will serve as the basis for the following steps and Tumor growth in the laboratory.
“We have, for the first time, been able to develop a bioink from breast tissue, which is devoid of cells capable of mimicking the mechanical and biochemical characteristics of the extracellular matrix of the human breast”, explains first author Barbara Blanco-Fernandez. study.
Tumor model construction
Once this bioink was obtained, formed by the ECM of pig breast tissue, the team used it to generate human breast tumors by 3D bioprinting. To do this, biotint is added human cancer cellsFactors such as type 1 collagen (present in large amounts in breast tumors) and other components that maintain the tumor’s ideal structure and rigidity. that’s a mix 3D. print in And after a few days of incubation, under adequate and fully controlled conditions, a human breast tumor is obtained.
The newly developed bioink highlights the importance of recreating the complexity of the extracellular matrix as well as the great potential of these materials for building tumor models by 3D bioprinting for the study of cancer. In addition, this model opens doors Development of more effective therapies and personalized therapies because tumors can be created using patient cells.
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