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An increasing number of young men and women under the age of 50 are suffering from gastrointestinal cancer – as reflected in a new study in South Australia – worrying international experts.
Long-term SA Cancer Registry data provide compelling evidence of a ‘significant’ increase in young-onset (18–50 years) gastrointestinal adenocarcinoma (cancer) over the past three decades, with Flinders University and other researchers using greater efforts to understand is invoked. and solve the growing problem.
Lead author Associate Professor Savio Barreto, with fellow researchers from Flinders University, SA Health, says: “The trend seen in the younger group of oesophageal, stomach, colon and rectum, and in older individuals over the age of 50, increased the incidence of pancreatic cancer. was not reflected.” and the University of California, Los Angeles (UCLA) in a new article in Cancer.
“This increased incidence, although evident in both sexes, was more pronounced in men than in women.
“Improved survival in the young-onset group was seen only in patients with colorectal cancer, but not in those with cancers of the esophagus, stomach, and pancreas.
The study requires a concerted effort to determine the socio-demographic factors underlying this disturbing trend so that preventive strategies can be developed.
Between 1990 and 2017, the registry treated a total of 28,566 patients diagnosed with colorectal, pancreatic, stomach or oesophageal adenocarcinoma. Of these, 2129 (7.5%) were in the age group of 18-50 years.
The number of young adults diagnosed with these cancers increased from 650 (incidence rate of 9.3/100,000 people) in the 1990s to 759 in the past 8 years of study (2010–2017, incidence rate of 12.89/100,000 people).
Co-lead author Professor Claire Roberts says the incidence rate of these cancers for men aged 18 to 50 has increased by 1% each year.
“The biggest concern is that we don’t know what causes this disturbing trend,” says Professor Claire Roberts, a Matthew Flinders Fellow at Flinders University.
“Youth-onset carcinogenesis is an area that warrants urgent research. We need to identify potentially modifiable factors that may enable us to halt the increasing incidence rate.”
As well as the potential roles of nutrition, including poor-quality diet and obesity, and drug and alcohol use, experts say these types of exposure before birth and in early life may accelerate the development of cancer resulting in cancer diagnosis. I may be younger.
Other socio-demographic factors need to be examined, including the susceptibility of different ethnic groups and the effects of education and income levels, said Associate Professor Barreto and UCLA Professor Stephen Pandol another in Frontiers of Oncology (DOI: 10.3389/fonk) says in the new paper. 2021.653289).
Researchers say the good news is that survival rates for gastrointestinal adenocarcinoma for individuals over the age of 50 have progressively improved over the past 28 years. But, this improvement has not been apparent in young adults in general, except in people with colorectal cancer.
The authors of the study intend to apply for funding to find answers to the questions raised by this research.
Article by Dominic Schell, Shahid Ullah, Mark E Brooke-Smith, Paul Hollington, Marina Yew, Christos S Karapetis, David I Watson, Stephen J Pandol, Gastrointestinal adenocarcinoma incidence and survival trends in South Australia, 1990–2017 (January 2022), Claire T. Roberts and Savio G. Barreto Published in Cancer DOI: 10.3390/cancer 14020275
Acknowledgments: This study was funded by the US National Institutes of Health, the US Department of Defense (Dr. Stephen Pandol, Director of Basic and Translational Pancreatic Research at Cedars-Sinai Medical Center) and the National Health and Medical Research Council of Australia and Flinders University went. (Dr Claire Roberts).
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