Thursday, December 08, 2022

SARS-CoV-2 is able to infect astrocytes and cause neuronal death

The neuroinvasion mechanism in lethal COVID-19 may also operate in mild COVID-19.

SARS-CoV-2 is able to reach Central nervous system (CNS) K covid-19 patientsinfect anthrocytes and Damage Neuronal Function and Viability, This is the surprising and salient result of a recent study published in the academic journal PNAS, which found “Displays structural and functional changes in brain tissue from patients with COVID-19which parallels the in vivo findings of cortical atrophy, neuropsychiatric symptoms and cognitive dysfunction,” according to Fernanda Krunflicklead author of the research.

In a longitudinal study conducted by researchers at the University of Washington, A total of 401 patients were analyzed, with a mean age of 62 years, infected between March 2020 and April 2021, scanned before and after infection. This allowed reporting of “atrophy and cognitive impairment (as determined by color trail tests) in orbitofrontal and parahippocampal regions”.

In addition, “the analyzed patients were infected between March and July 2020 (and therefore most likely to have been infected) SARS-CoV-2 . original seppa of), and orbitofrontal area atrophy and cognitive dysfunction (longer time to perform the color test and poorer performance in the verbal memory task) were also observed,” explains Krunfly.

In fact, “patients with mild COVID-19 also had cortical atrophy in the superior temporal gyrus, which had already been described in a group of patients with severe SARS-CoV-2 infection.” In addition, the researchers noted that “high levels of symptoms of anxiety correlated with atrophy of the orbitofrontal cortex, a region previously associated with anxiety disorders.”

Symptoms of anxiety and depression associated with SARS-CoV-2

After analyzing all the results, the researchers also suggest that “ Symptoms of anxiety and depression are connected, at least in part, with SARS-CoV-2 infectionA hypothesis supported by a recently discovered association between anxiety and reactive astrogliosis in post-Covid-19 patients”.

“The neuroinvasion mechanism in lethal COVID-19 may also operate in mild COVID-19.”

In summary, according to Krunfly, “the findings are consistent with a model in which SARS-CoV-2 is able to reach the CNS of covid-19 patients, infecting astrocytes through interaction with NRP1 and secondly affecting neuronal function and hurts viability.” Certain changes that “may contribute to the changes in brain structure observed here and elsewhere that lead to the neurocognitive and neuropsychiatric dysfunction seen by some patients with COVID-19.”

This research is “a caveat that Deadly Covid-19. neuroinvasion mechanisms in They can even be operational in mild COVID-19. However, it is important to note that the study was limited because neuroimaging and cognitive tests were obtained from a different cohort than from the lethal COVID-19 cohort, with only a few individuals showing evidence of astrocytic invasion. However, interventions aimed at treating COVID-19 should also include ways to prevent its invasion. CNS. SARS-CoV-2 in and/or its replication in astrocytes”, concludes Krunfly.

While it may include statements, data or notes from health institutions or professionals, the information contained in medical writing is edited and prepared by journalists. We advise the reader to consult a health professional on any health-related questions.

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