Tuesday, January 31, 2023

Spanish blow for blood sugar and cholesterol: why they go up even if you diet according to science

High blood cholesterol and glucose are both known cardiovascular risk factors, among many others. Maintaining its levels in an adequate range, without excess or deficiency, is one of the main objectives of prevention at the primary care level. However, this is not always an easy task.

they appear on several occasions genetic factors Cannot be modified by diet or lifestyle, as is the case with the well-known familial hypercholesterolemia, where total cholesterol and LDL cholesterol levels skyrocket for no apparent reason. Until now, the genes responsible for only 80% of cases were known, but a new work of Spanish origin has discovered a new mutation: L gene SREBF2,

The disease, known as ‘autosomal dominant hypercholesterolemia’ or ADH, is a disease of genetic origin. it’s known The LDLR gene is the cause in most patients. About 80% of cases, although there are other genes known as APOB and PCSK9, which account for about 1%.

In this new study, led by researchers from the INCLIVA Health Research Institute of the Hospital Clínico de Valencia, the aim was to identify new genes potentially responsible for ADH, which would help to detect many other patients, thus pursue the application of appropriate medical treatment And healthy lifestyle habits correspond to the disease, thus reducing cardiovascular risk in the long term.

detect early

study, led by Felipe Javier ChavesHead of INCLIVA’s Genomics and Diabetes Unit and researchers from the Center for Biomedical Research Network for Diabetes and Associated Metabolic Diseases (CIBERDEM) of the Carlos III Health Institute, recently published in the journal. biomedicine,

Chávez and his colleagues studied several genes as potential candidates in a 41-patient group with ADH, who did not have any mutations in other genes known to be responsible for the disease. These potential genes were specifically selected for their involvement in metabolic pathways related to lipids, and cholesterol in particular.

It was possible to identify a mutation in the SREBF2 gene in one patient, so the same mutation was studied in his family. Thus, it was found that all relatives with the same genetic mutation also shared two known cardiovascular risk factors, namely high cholesterol and high glucose level being diagnosed with diabetes those old relatives

This mutation is found in the promoter region of a gene involved in its regulation, so it was studied whether this mutation could enhance gene expression.

According to their findings, mutation of the SREBF2 gene leads to increased transcription of the gene, i.e. Increases its expression in various cell groups such as liver, intestine or adipocytes or fat cells, although in different quantities.

Not all cell groups increase their gene expression in the same way, although the mutation has, to a greater or lesser extent, increased blood cholesterol levels,

it also increases sugar

Previous studies had already suggested the possibility that SREBF2 mutations were the cause of hypercholesterolemia or that they could influence already high cholesterol levels in patients with LDLR gene mutations. This research has shown that the SREBF2 mutation, by itself, is capable of causing familial hypercholesterolemia.

In addition, the detected mutation also gives rise to high glucose and insulin levels, suggesting that it also has a role in modulating glucose metabolism. Some relatives of patients who participated in the study were already diagnosed with diabetes, but others were at prediabetes level (high blood sugar levels, without reaching the threshold of diabetes as a diagnosis) and none of these individuals had any other There wasn’t a genetic change that could explain his high blood sugar beyond the SREBF2 gene.

Finally, the authors suggest that this mutation is capable of raising both cholesterol and glucose levels in humans, but more study will be needed To demonstrate a causal relationship between this mutation and familial hypercholesterolemia.

Nation World News Desk
Nation World News Deskhttps://nationworldnews.com
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