Saturday, October 1, 2022

Study: Combination of COVID-19 vaccines for booster safe, effective

13 October (NWN) — Combining COVID-19 vaccines with booster doses is safe and effective, according to results from a National Institutes of Health-led study released Wednesday.

This means that receiving a booster dose of a vaccine that is different from the shot type initially given provides enough immunity to protect against the virus and that any serious side effects remain rare, the researchers said.

However, Moderna and Pfizer-BioNTech vaccines produced a stronger immune system response than Johnson & Johnson, even after the latter two doses, the data showed.

According to the researchers, people who received the Johnson & Johnson vaccine had higher antibody levels after receiving a booster shot made by Moderna or Pfizer-BioNtech than those who were given boosters from Johnson & Johnson.

Antibodies are proteins produced by the immune system to fight infection, and vaccines are designed to increase their levels in response to viruses.

The study was posted online and has yet to be peer-reviewed for publication in a medical journal.

However, the findings will be presented to the Food and Drug Administration’s advisory committee on vaccines on Friday, according to the Centers for Disease Control and Prevention.

The Advisory Committee on Immunization Practices is set to meet on Thursday and Friday to recommend the agency authorize booster shots for Moderna and Johnson & Johnson vaccines.

To date, only a booster dose of the two-shot Pfizer-BioNTech vaccine has been approved.

For the study, 458 volunteers were given vaccine boosters four to six months after receiving their initial vaccination with one of three approved vaccines.

The participants were divided into different groups based on their original vaccinations and were given one of three boosters made by Pfizer-BioNtech, Moderna, or Johnson & Johnson.

For example, those who were originally given Moderna’s two-dose vaccine got either a matching booster or a “compound” from Pfizer-BioNtech or Johnson & Johnson, he said.

The participants’ antibody levels were measured two and four weeks after giving the booster, the researchers said.

The boosters increased antibody levels by more than 50-fold, suggesting that they significantly add to the immune protection offered by the vaccines, as the data showed.


Nation World News Desk
Nation World News Desk
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