Thursday, February 9, 2023

Study finds high coffee consumption may reduce severity of NAFLD in type 2 diabetics

a study of University of Coimbra (Portugal) Turns out that the caffeine, polyphenols, and other natural products in coffee may help reducing the severity of non-alcoholic fatty liver disease (NAFLD) In overweight people with type 2 diabetes (T2DM).

nonalcoholic fatty liver is a collective term for liver disorders for One fatty deposits in the liver, can provoke liver fibrosisthat can move cirrhosis (liver scarring) and liver cancer. NAFLD is not a result of excessive alcohol consumption but rather a result of unhealthy lifestyle, low exercise and high-calorie diet.

participants in the studio with a increase in coffee consumption they had Healthy liver. Those with higher levels of caffeine were less likely to have liver fibrosis, while higher levels of non-caffeinated coffee components were significantly associated with lower fatty liver index scores.

The study, published in the scientific journalNutrients‘, suggests that, in patients type 2 diabetes and overweightAnd increase in coffee consumption is associated with a Less severe nonalcoholic fatty liver disease.

The researchers surveyed 156 borderline obese middle-aged participants about their coffee consumption, 98 of whom had type 2 diabetes, and provided 24-hour urine samples.

They were used to measure caffeine and non-caffeine metabolites, ie the natural products of the breakdown of coffee by the body. This method follows the recent shift towards urinalysis, rather than self-reported consumption, to obtain more defined quantitative data on coffee intake.

Caffeine intake is associated with a reduction in liver fibrosis in NAFLD and other chronic liver diseases., Other components of coffee, including polyphenols, have been suggested to reduce oxidative stress in the liver, Shortage in return Reduction of fibrosis and improvement of glucose homeostasis in both healthy and overweight subjects. All these factors can also reduce the severity of type 2 diabetes.


“Due to modern diet and lifestyle changes, obesity rates are rising and the incidence of both type 2 diabetes and non-alcoholic fatty liver disease is on the rise, which may eventually become more serious and irreversible conditions that overwhelm health care systems.” Our research is the first to look at whether higher cumulative amounts of caffeine and non-caffeine metabolites in urine are associated with lower NAFLD severity in people who are overweight and have type 2 diabetes,” commented. Dr. John Griffith Jones, lead author of the studyPrincipal Investigator at the Center for Neuroscience and Cell Biology Coimbra University.

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