prevent, delay and improve The treatment of Alzheimer’s disease is one of the major public health objectives worldwide. In developed countries such as Spain, where longer life expectancy brings with it an increase in these chronic diseases, it is especially important to guarantee Quality of life and more years of autonomy for patients.
Both diet and exercise can protect the brain, but studies are looking for more specific forms of prevention. and a recently published study The Journal of Physiology Point to a way to delay the onset of Alzheimer’s symptoms, even after the long neurodegenerative process has begun. they will be enough six minutes daily exercise,
According to this task, the key has to be completed short but high intensity session, In this case, the practice of cycling would have been shown to thus increase the output of a special proteins Which is essential in brain formation, learning and memory. also protects against cognitive decline linked to age.
[Estos son los mejores ejercicios físicos para evitar el alzhéimer]
it’s protein brain-derived neurotrophic factor (BDNF), which promotes neuroplasticity (the brain’s ability to form new connections and pathways) and neuron survival,
Previous animal studies have already shown that increased availability of BDNF promotes formation and storage improves memory Learning and increases cognitive performance, All of these functions are important for protecting the brain from deterioration.
As Travis Gibbons, a researcher at the University of Otago in New Zealand and lead author of the study, explains, “BDNF has shown promise in animal models, but pharmacological interventions have not been successful. Take advantage of its brain protective potential safely in humans.”
For this reason, he explains, “they have discovered new non-pharmacological approaches able to naturally increase BDNF production and preserve the human brain’s ability to experience healthy aging.”
Thus, Gibbons and his colleagues investigated Potential effect of both fasting and exercise on BDNF production, They compared the following factors, both individually and in combination, in a study with 12 participants (six men and six women) between the ages of 18 and 56.
Fasting for 20 hours.
– Light exercise (low-intensity cycling for 90 minutes).
– High-intensity exercise (six minutes of HIIT-type cycling).
Exercise along with fasting.
According to the results of the study, Brief but intense exercise was the most effective way to increase BDNF levels Compared to a fasting day with or without prolonged light exercise. BDNF increased 4-5 fold compared to fasting or prolonged light activity.
The reason for these differences is still unknown and more research is needed to understand the underlying physiological mechanisms. One of the hypotheses is believed to be brain substrate switching and glucose metabolismWhich is usually the main source of brain fuel.
Thus, while doing intense exercise, The major form of energy is lactate, not glucose., In this case, the brain’s transition from glucose to lactate consumption would initiate metabolic pathways that would lead to increased production of BDNF in the blood.
On the other hand, an increase in BDNF may also be due to To increase the number of platelets, which store this factor in large quantities. Exercise increases the number of platelets by up to 20%, but not as much as fasting.
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