Of all the types of cancer that can affect a person, oral cancer is 13th most common Nearly half a million cases were diagnosed worldwide in 2020. However, since it occurs in one of the most accessible areas of the human body, it is one of the Better detection and higher survival rates: 90% of patients with tumors up to two centimeters are alive after five years.
In this high rate, early detection of the disease plays a fundamental role and that is where the study published by a group of researchers from the University of Florida comes in handy. In the field of biosensor, the team led by doctor Ming’an Jian has proposed A test kit with a biosensor that allows anyone to do it at home and get results quicklyAccording to Interesting Engineering Medium.
one in the medical industry Different types of tests to detect this type of cancer, but most of them need to be done in a laboratory by professionals and are expensive. Researchers attribute this type of testing “low sensitivity and lack of specificity”, for which they consider a system necessary more accessible and it allows immediate results,
In the study, a method has been developed published in the Journal of Vacuum Science and Technology under the title “High-sensitivity CIP2A detection for oral cancer using a fast transistor-based biosensor module”. point of care (referring to tests at the point of care and not at a health system facility) which include A biosensor consisting of a circuit board and a sensor strip, device that uses test strips, similar to a glucometer Quickly indicates levels of certain cancer biomarkers in oral fluid,
“Typically, the test fluid is introduced into a small fluid channel at the tip of the sensor strips. Some electrodes are located within the fluid channel and On the surface of these electrodes are antibodies against specific proteins present in human oral cancer lesions., Short electrode pulses are sent through these electrodes during detection, and then the circuit board module analyzes this signal and Generates a four digit number which is related to its concentration”, explains Mingan Jian in the study.
The protein he’s referring to is CIP2A, and it’s a biomarker for the most common form of oral cancer, which is oral squamous cell carcinoma and constitutes 90% of cases of this type of cancer. With this device, one can know the concentration of this protein, which is present in most oral cancers, without the need to send samples to a lab or go there to get tested.
system is also shown Six times higher sensitivity than ELISA test kitOne of the commercially available detection methods used for this type of disease.
Study authors continue to work Improve the performance of your biosensor and expand its detection capabilities For other types of cancer biomarkers.
