Thursday, February 9, 2023

They develop a predictor of risk of progression of breast precancerous cells

molecular analysis of ductal carcinoma in situ (DCIS), the most common precursor to invasive breast cancer, has allowed the development new genomic classifier To predict the recurrence or progression of these types of cells.

This can be seen from the research published in the journal ‘Cancer Cell’, led by researchers from Stanford University (USA), including José Antonio Cione, head of the Cancer Computational Biology Group at the Val de Hebron Institute of Oncology (VHIO), Barcelona. .

As the Barcelona hospital explained in a statement on Monday, DCIS is a non-invasive or pre-invasive breast cancer It begins in the milk ducts, although it is not life-threatening, but there is an increased risk of becoming more severe later.

The project, which has received support from the “La Caixa” Foundation, has produced the first breast precancer atlas that can help accurately Identify which of these DCISs are most at risk Recurrence or progression of the disease.

Researchers analyzed samples from patients who had undergone surgery to remove DCIS And they identified 812 genes associated with cancer progression during the next five years of a patient’s life, and developed a classification for these.

Thanks to the classifier, researchers were able predict the risk of developing breast cancerand further discovered that pathways associated with recurrence include proliferation, immune response, and metabolism.

The work is part of the ‘Human Tumor Atlas Network’, funded by the United States National Cancer Institute, and used data from two independent groups to carry it out.

A unique aspect of this study is that Characterization of the tumor microenvironment with laser microcapture and multiple identification of proteins.

Postdoctoral researcher and study participant Dr. Belen Rivero at Stanford University reports that they have achieved Identify four subtypes of the tumor microenvironment associated with DCIS, which is characterized by a distinct cellular composition in terms of immune and stromal cells”.

“In addition, the presence of certain cell types, such as CD4 T cellsDendritic, monocytes or macrophages were higher in patients who presented with a recurrence, compared to those who did not”, Rivero reported.

The doctor pointed out that “there may be an abundance of some of these cell types DCIS linked to increased risk of recurrence and even invasive carcinoma (IBC)”, something particularly relevant as it shows that “both tumor cells and those present in the tumor microenvironment play an important role in the recurrence of DCIS or progression to breast cancer”.


Nation World News Desk
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