Friday, January 27, 2023

They discover mechanisms that link diabetes to an increased risk of Alzheimer’s

Diabetic supports soluble forms amyloid betawhich are particularly toxic and harmful to neuronal tissue… This is a new scientific finding that is related to this disease Alzheimer’sAccording to a study in which researchers University of Cadiz Monica Garcia Aloza why maria vargas soriawith professor of Department of Physiology from University of Granada (UGR) Juan Jose Ramos Rodriguez,

Diabetes is commonly recognized as a risk factor for dementia, but the mechanism of this association was not fully understood. Now, the details of the process of Amyloid beta peptide deposition in the combined disease model of Alzheimer’s why diabetes provides a new therapeutic target Which has to be worked on to slow or stop the development of this dementia, the study authors point out.

Thus, this work elucidates one of the ways in which diabetes or pre-diabetes contributes to cognitive decline and accelerates disease progression. Alzheimer’s,

Study describes a new development amyloid beta pathology in patients with Alzheimer’s Those who also have prediabetes or type 2 diabetes.

Based on the detection of progress as distinguished from the novelty of the results obtained amyloid beta pathology when you only suffer from illness Alzheimer’s And a different development when suffering from this dementia with type 2 diabetes or prediabetes.

In the combined model, a large accumulation of beta amyloid peptide Level vascularknown asBeta-amyloid angiopathy. Furthermore, diabetes favors soluble forms of the amyloid beta peptide, which are the most toxic and damaging to neuronal tissue.

this modification beta-amyloid pathology Increases oxidative stress at the neuronal and vascular level. All this facilitates and increases the rupture of blood vessels in the brain. nerve death disease specific Alzheimer’s,

The probe has been developed thanks to the sophisticated technology of multiphoton microscopy In a living animal, that allows the same animal and brain pathology to be monitored over time.

‘In vivo’ multiphoton microscopy It is a technique within the reach of some laboratories, but capable of offering data and images that cannot be achieved with other techniques.

juan jose ramosco-authors of the study explained that “andThis reduces the number of animals needed in research, undoubtedly a huge advantage over more rudimentary techniques, which triple the number of animals needed to conduct a similar study., researchers of UGRconcluded that “The next question we ask ourselves is this: can we stop or reduce the progression of beta-amyloid pathology and its consequences by controlling diabetes pathology?,

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