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Wednesday, November 30, 2022

They restore the function of dead pigs’ organs with technology applied to humans.

Research from Yale University has concluded that it will increase the availability of implants and help treat patients with ischemia.

Domenico Chiappe

According to a statement issued after the institute published its findings, organs and tissues of lifeless pigs were able to function for an hour after their death, after being treated with a cellular protective fluid developed by scientists at Yale University. have returned for. Magazine ‘Nature’. By restoring blood circulation, it “could help extend the health of human organs and expand the availability of donor organs during surgery.”

Already in 2019 the research group had managed to restore some function in the brain of a dead pig – affected by a lack of blood supply – and hope to achieve “something similar in other vital organs, which may be transplantable”. hypothesis was proposed. Nenad Seston, professor of neuroscience who led both studies.

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The technology implemented at this time, called OrganEx, consists of an “experimental fluid containing compounds that can promote cellular health and suppress inflammation throughout the pig’s body,” via a perfusion machine. They are similar to those used to pump blood during surgery. The pigs were placed in cardiac arrest, first anesthetized, and “treated with OrganEx one hour after death.”

Results were seen after six hours. “Some key cellular functions” were activated in the heart, liver, and kidney, and “some organ functions were restored,” such as cardiac electrical activity (i.e., the heart was contracting). There was also circulation “all over the body”. “We were surprised,” Seston said. “Usually when the heart stops beating, organs begin to swell, blood vessels collapse and circulation is blocked.” In the brain, however, there was no electrical activity.

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The discovery could “prolong the lifespan of organs in human patients,” “expand the availability of donor organs for transplantation,” and “help treat organs or tissues damaged by ischemia during a heart attack or stroke.” Is.”

David Andrijevic, a neuroscientist at Yale School of Medicine and co-senior author of the study, said, “Not all cells die immediately, there is a long chain of events where you can intervene, prevent and suppress some cellular function.” can be reinstated.”

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