The technique consists of aromatic organs so that their metabolic functions are activated.
The limited number of organs is also due to the fact that in clinical practice they are not stored on ice for more than 12 hours. Photo: Shutterstock.com.
Advances at Zurich University Hospital have opened a window to increase the number of transplantable organs and reduce waiting lists. he receives thanks for giving it Second chance to organs that would be rejected in normal procedures.
And transplant of Liver The requirement that the organ spend no more than twelve hours outside the body, a handicap that may have been eliminated thanks to a new technology that allows it to be preserved for at least three days, as shown with a Patient Who is still healthy one year after receiving the organ.
The technology still needs more trials before it can be considered for general use, but it is expected to “increase the number of transplantable organs as well as reduce waiting lists and, above all, save many lives”. Opens a window for, explains a signatory. Investigation, Lucia Bautista Borrego.
The difference between seeking transplant of Liver and their availability. limited number of organs, moreover, This is because clinical practice is to keep them on ice for no more than 12 hours.
The team, led by Pierre-Alain Clavien of Zurich University Hospital, managed to preserve it. Liver Thanks to a machine outside the body that performs a technique known as ex situ normometric perfusion. The results can be read in Nature Biotechnology.
life saving techniques
The technique involves introducing a liquid inside the organs (perfandir) within the range of body temperature (34 to 37 °C). This means that their metabolic functions are active, not “at rest,” as is the case with hypothermic perfusion (at low temperatures), explains Lucia Bautista. For this the team uses human blood from a blood bank, which is “Makes perfusion more like it does in vivo,
What makes the team’s technology “special” is its use of a machine developed with engineers from the Federal Polytechnic School of Zurich (ETH), which Allows monitoring and control of multiple functionality parameters, “With this we have been able to keep the liver in good condition for several days,” says Bautista.
Once transplanted, in May 2021, Liver functions normally, with “minimal injury” By returning flow to the internal blood vessels, the authors write.
Patient She needed only a basic immunosuppressive regimen for the first six weeks and “rapidly achieved quality of life, without any signs of liver damagesuch as rejection or injury to the bile ducts, which remain healthy for a year after the operation”, the study said.
second life for limbs
The recipient of the organ was a 62-year-old man who suffered from advanced cirrhosis, severe portal hypertension, and multiple and recurrent hepatocellular carcinoma (HCC), who had been exposed to the technique to which the organ was subjected.
Liver was not valid for transplant in a normal process and was rejected by other centers, as it came from a Patient with sepsis and had a tumor that at the time was not known to be benign, which was determined later. that Patient was subject to, in turn, a transplant multiple of LiverBazo and gut.
“If we hadn’t used it, Liver It must have ended up in the garbage. ie, basically, the purpose of our project: Being able to use organs that can be evaluated and even reconstituted for transplant, reducing waiting lists and saving lives”, he points out.
keep Liver Out of body gave the option to evaluate and treat it. One of the “obvious advantages” of ex situ perfusion is the fact that the drugs can be used at high doses, as they do not produce secondary effects in other organs, for example “in cases of various infections, which may be associated with this disease.” The case was in the case”.
A multitude of therapeutic options for specific pathologies
Bautista stresses that the therapeutic options are “endless, each specific pathology can, in principle, be treated ex situ with a specific treatment for each percussive organ”.
in the first transplant, The liver was kept outside the body for three days, because “the patient needed it and received it as quickly as possible”.“As its functionality was restored, but in laboratory tests the team has been able to perfandir organs for twelve days.
Spanish researchers say that any organ that is perfused for several hours is likely to be able to do so for a long time, such as the heart, kidneys or lungs. This technique should be adapted to the needs of each organ.which “can be redeemed for” transplant,
In order to fully integrate this technology into clinical practice, “clinical trials that demonstrate its safety using noninvasive organs that can be transplanted,” are needed. This requires “a few years to be possible, but we are working on it,” he concluded.
Source consulted here.