Organic chemists from the University of California at Los Angeles (USA) have created the first A synthetic version of a molecule recently discovered in a sea sponge, Known as ‘Lysodendoryx florida’, which may have therapeutic benefits for the disease Parkinson’s and similar disorders.
According to their study published in the scientific journal Science, the molecule, known as lysodendoric acid A, counteracts other molecules that can damage DNA, RNA and proteins and even destroy entire cells. can do.
The research team used an unusual and little-known compound called cyclic allene To control a key step in the chain of chemical reactions needed to produce a usable version of a molecule in the laboratory. This advance may prove beneficial in the development of other complex molecules. drug research.
He said, “Most drugs today are made using synthetic organic chemistry, and one of our roles in academia is to establish new chemical reactions that can be used to rapidly produce drugs and molecules with complex chemical structures that benefit the world.” can be done to develop.” Neel GargCorresponding author of the study.
According to the researcher, a key factor that complicates the development of these synthetic organic molecules is chirality. Many molecules (including lysodendoric acid A) can exist in two different forms that are chemically identical but are three-dimensional mirror images of each other, such as left- and right-handed. Each version is known as an enantiomer.
When used in pharmaceuticals, an enantiomer of a molecule can have beneficial therapeutic effects, while the other may do nothing, or may even be dangerous. Unfortunately, the manufacture of organic molecules in the laboratory often produces a mixture of both enantiomers, and chemically removing or reversing the undesired enantiomers leads to difficulties, costs, and delays in the process.
To meet this challenge and quickly and efficiently produce only the lysodendioric acid A enantiomer that is found almost exclusively in nature, Garg and his team used cyclidine as an intermediate in their 12-step reaction process. Elaine was used. was first discovered in the 1960s highly reactive compounds They had never before been used to make molecules of such complexity.
“Cyclic allenes have been forgotten since their discovery more than half a century ago. This is because they have unique chemical structures and They only exist for a fraction of a second when they are generated.Garg explained.
The team found that they could use the compounds’ unique properties to generate a special chiral version of the cyclic allene, which in turn caused chemical reactions that ultimately almost exclusively produced the desired enantiomer of the A. lysodendoric acid molecule. .
Although the ability to synthetically produce a lysodendoric acid A analog is the first step in testing whether the molecule may have suitable properties for future therapies, the method of synthesizing the molecule is something that remains to be done. Can immediately benefit other scientists involved in drug researchsaid the chemists.
“Challenging conventional thinking, we have now learned how to make cyclic allenes and how to use them to make more complex molecules such as lysodendoric acid A. We hope that cyclic allenes will be used by others.” May go create new drugsGarg fumed.