Saturday, December 10, 2022

US in process of releasing monkeypox vaccine from national stockpile for ‘high risk’ people

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By Jacqueline Howard and Virginia Langmead | Nation World News

The United States is responding to a request from the country’s Strategic National Stockpile to release a monkeypox vaccine as the global outbreak of cases is under investigation.

The US Centers for Disease Control and Prevention said on Monday that there is one confirmed case of monkeypox and four suspected cases in the United States.

“I can report that the National Stockpile has been requested to release the Genios vaccine for some high-risk contacts of some of the initial patients, so this is actively happening right now,” said Dr. Jennifer McQuiston, deputy CDC. Director of the Department of High Outcome Pathogens and Pathology within the National Center for Emerging and Zoonotic Infectious Diseases said Monday.

McQuiston said the United States has a “good stock” of the vaccine as it prepares for the prospect of needing to use doses for smallpox.

In the United States, the two-dose Jynneos vaccine is licensed to prevent smallpox, and specifically to prevent monkeypox.

“Right now, we have over 1,000 doses available, and we expect this level to rise very quickly in the coming weeks as the company provides more doses to us,” McQuiston said.

There is another smallpox vaccine licensed in the United States, ACAM2000, which can be used to prevent monkeypox, she said, and there are more than 100 million doses in the country.

“ACAM2000 is an older generation smallpox vaccine with some potentially significant side effects. So the decision to use it widely has to have some serious discussion behind it,” McQuiston said.

Overall, “we’re hoping to maximize vaccine delivery to the people we know will benefit from it,” she said. “Those are people who have a known monkeypox patients, health care workers, very close personal contacts, and especially those who may be at high risk for serious illness.”

The CDC says the confirmed US case of monkeypox is in one man in Massachusetts, and four cases of orthopox are in men. Orthopox refers to the pox virus in general.

McQuiston said health care providers should assume these orthopox cases are monkeypox.

“It is likely that additional cases are going to be reported in the United States,” she said.

McQuiston said the CDC expects to receive samples from the four suspected cases “today or tomorrow” for further analysis. Laboratories within the CDC’s laboratory response network can test for an orthopox virus, and then have the agency specifically confirm monkeypox through PCR tests, which take “a few hours” to run, she said.

“Since the CDC receives a sample, we can do our monkeypox confirmatory PCR test on the same day. We’re actually seeing a change in the few days from when a suspected patient can come to a doctor’s attention, they can get that initial state LRN lab result,” McQuiston said.

CDC sequencing of the sample went “really quickly” from a confirmed case in Massachusetts, and within 48 hours, researchers were able to see that it closely matched a case in Portugal.

“This process used to take up to two weeks at first, but we were able to post it within two days because we think this kind of public sharing of initial sequence data is going to be important for all countries so that we All we can do is better understand how the virus is spreading around the world,” McQuiston said.

The CDC’s chief medical officer for HIV prevention, Dr. John Brooks, said monkeypox is not spread through sex, but can be spread through contact during sex.

“Monkeypox is not a sexually transmitted infection in the usual sense, but it can be transmitted through sexual and intimate material, as well as through personal contact and shared bedding and clothing,” Brooks said Monday.

Anyone can get or spread monkeypox, but in the latest global outbreak a “significant fraction of cases” are occurring among gay and bisexual men.

“Certain groups may have a higher potential for risk right now, but by no means present an increased risk of exposure to monkeypox specifically for the gay and bisexual community in the US,” Brooks said. “Anyone, Anyone, Can Evolve” [and] Monkeypox infection continues to spread, but … many of those affected by the current global outbreak have been identified as gay and bisexual men.”

Brooks said the CDC now decided to hold a news conference about the outbreak because LGBTQ Pride Month usually begins around Memorial Day weekend, and officials wanted to make sure the community was aware of the situation. He also urged doctors to be on the lookout for the disease, as it can look like other types of STDs.

He added that the rash is “appearing in different parts of the body, as we would normally expect to see it.”

“In some cases, it has produced anal or genital sores that look like other diseases such as herpes, chickenpox or syphilis. So anyone who has a rash or sores on their genitals, anus or any other place they have previously Get a thorough evaluation for that rash, but especially for sexually transmitted infections and other diseases that can cause a rash, he said.

“What we’re trying to do by taking note of the fact that some of these cases have genital and perianal presentation is to remind people that people can come in for evaluation to see what they think is an STD. , but we’d provider like to think ‘could it be monkeypox too?’ If the circumstances suit the story.”

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