Friday, January 27, 2023

Why do we consume more of hypercaloric, fatty and sweet foods?

High-calorie foods (high in fat, oil, and sugar) may taste good, but they often lead to overeating. This leads to obesity and serious health problems. but, What triggers the brain to overeat? This is the question researchers from Osaka Metropolitan University (Japan) asked themselves.

The answer is found in a gene, called CREB-regulated transcription coactivator 1 (CRTC1). This, according to experiments done in rats, responsible for reducing obesity, The findings, published in the scientific journal ‘FASEB Journal’, show that suppression of CRTC1 in rodents causes them to become obese.

To elucidate the mechanism by which CRTC1 suppresses obesity, a research group led by Shigenobu Matsumura of Osaka Metropolitan University’s Graduate School of Human Life and Ecology focused on Neurons that express the melanocortin-4 receptor (MC4R) responsible for appetite control, Since mutations in the MC4R gene cause obesity, the researchers chose to study them.

consequently, A strain of mice normally expresses the CRTC1 gene, except in neurons that gain MC4R, In them, specifically, the effect of this gene was blocked to see if doing so affected obesity and diabetes.

When fed a standard diet, mice with this modification showed no change in body weight compared to control mice. Even then, When CRTC1-deficient mice were reared on a high-fat diet, they ate more, became more obese develop diabetes as well, compared to control mice.

This is why, as Professor Matsumura concludes, the CRTC1 gene in the brain is responsible for preventing us from eating hypercaloric, fatty and sugary foods, “We hope it will give us a better understanding of why people overeat,” the professor predicted optimistically.

Nation World News Desk
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